| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Van Blitterswijk, Clemens A.
Maastricht University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2023Direct deep UV lithography to micropattern PMMA for stem cell culturecitations
- 2023Polymer film-based microwell array platform for long-term culture and research of human bronchial organoidscitations
- 2023Complementary Supramolecular Functionalization Enhances Antifouling Surfacescitations
- 2022Assessment of Cell-Material Interactions in Three Dimensions through Dispersed Coaggregation of Microsized Biomaterials into Tissue Spheroidscitations
- 2021Bioprinting Via a Dual-Gel Bioink Based on Poly(Vinyl Alcohol) and Solubilized Extracellular Matrix towards Cartilage Engineeringcitations
- 2021Thin fluorinated polymer film microcavity arrays for 3D cell culture and label-free automated feature extractioncitations
- 2017Development of a microfluidic platform integrating high-resolution microstructured biomaterials to study cell-material interactionscitations
- 2016Mimicking natural cell environments: design, fabrication and application of bio-chemical gradients on polymeric biomaterial substratescitations
- 2016Surface energy and stiffness discrete gradients in additive manufactured scaffolds for osteochondral regenerationcitations
- 2016The Effects of Crystal Phase and Particle Morphology of Calcium Phosphates on Proliferation and Differentiation of Human Mesenchymal Stromal Cellscitations
- 20163D high throughput screening and profiling of embryoid bodies in thermoformed microwell platescitations
- 2016Flexible Yttrium-Stabilized Zirconia Nanofibers Offer Bioactive Cues for Osteogenic Differentiation of Human Mesenchymal Stromal Cellscitations
- 2015Distribution and Viability of Fetal and Adult Human Bone Marrow Stromal Cells in a Biaxial Rotating Vessel Bioreactor after Seeding on Polymeric 3D Additive Manufactured Scaffoldscitations
- 2014A biocomposite of collagen nanofibers and nanohydroxyapatite for bone regenerationcitations
- 2010Biomimetic calcium phosphate coatings on recombinant spider silk fibrescitations
- 2008Comparative in vivo study of six hydroxyapatite-based bone graft substitutescitations
- 2007Biological performance in goats of a porous titanium alloy-biphasic calcium phosphate compositecitations
- 2006Influence of physico-chemical properties, macro- and microstructure on osteoinductive potential of calcium-phosphate ceramicscitations
- 2006Relevance of osteoinductive biomaterials in critical-sized orthotopic defectcitations
- 20053D microenvironment as essential element for osteoinduction by biomaterialscitations
- 2004Influence of octacalcium phosphate coating on osteoinductive properties of biomaterialscitations
Places of action
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article
Mimicking natural cell environments: design, fabrication and application of bio-chemical gradients on polymeric biomaterial substrates
Abstract
Gradients of biomolecules on synthetic, solid substrates can efficiently mimic the natural, graded variation of properties of the extracellular matrix (ECM). Such gradients represent accessible study platforms for the understanding of cellular activities, and they also provide functional supports for tissue engineering (TE). This review describes the most relevant methods to produce 2-dimensional (2D) as well as 3-dimensional (3D) gradient supports for cell manipulations, and also addresses the response of cells from different origins when seeded on these constructs. The fabrication strategies summarized encompass the combination of polymer and surface chemistries, micro-and nano-engineering construction strategies and biotechnological approaches. This multidisciplinary scheme has enabled the design and realization of diverse, synthetic supports as cellular environments, spanning from the first gradient self-assembled monolayer (SAM) to multilayers, and hybrid constructs mimicking the complexity of natural tissue environments. The standing challenge is bringing these advances in the fabrication of supports to a dynamic functioning in space and time, towards the successful imitation of the most complex bio-chemical system ever studied: our body.