| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Rychlewska, Urszula
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2020Zinc(II) complexes with aromatic nitrogen-containing heterocycles as antifungal agents: Synergistic activity with clinically used drug nystatincitations
- 2020Modulation of the structure of octahedral 1,3-pdta-nickel(II) complex by introducing methyl substituents at the central 1,3-propanediamine carbon atom: Stereospecific formation and the crystal structure of [Mg(H2O)5Ni(2,2-diMe-1,3-pdta)]·1.5H2Ocitations
- 2017Mononuclear gold(iii) complexes with l-histidine-containing dipeptides: tuning the structural and biological properties by variation of the N-terminal amino acid and counter anioncitations
- 2017Mononuclear gold(III) complexes with phenanthroline ligands as efficient inhibitors of angiogenesis: A comparative study with auranofin and sunitinibcitations
- 2015Chalcogenated (S)-(-)-nicotine derivatives as chiral linkers for 1D coordination polymerscitations
- 2011Structural diversification of the coordination mode of divalent metals with 1,3-propanediaminetetraacetate (1,3-pdta): The missing crystal structure of the s-block metal complex [Sr<inf>2</inf>(1,3-pdta)(H<inf>2</inf>O) <inf>6</inf>]·H<inf>2</inf>Ocitations
- 2009Variety of polymorphic forms contrasted with uniform crystal packing in sparteine ML<inf>2</inf> complexes: Crystal structure, spectroscopic and magnetic properties of (-)-α-isosparteine and (-)-sparteine complexes with CuBr<inf>2</inf>citations
- 2008Coordination behaviour and two-dimensional-network formation in poly[[μ-aqua-diaqua-(μ5-propane-1,3-diyldinitrilo-tetra-acetato) -dilithium(I)-cobalt(II)] dihydrate]: The first example of an M <sup>II</sup>-1,3-pdta complex with a monovalent metal counter-ioncitations
- 2005Highly selective crystallization of metal(II) ions with 1,3-pdta ligand: Syntheses and crystal structures of the [Mg(H<inf>2</inf>O)<inf>6</inf>][Cd(1,3- pdta)(H<inf>2</inf>O)]·2H<inf>2</inf>O and two isomorphic [Zn(1,3-pdta)]<sup>2-</sup> complexescitations
- 2005Layered crystal structure of the trans(O<inf>5</inf>O<inf>6</inf>) isomer of potassium (1,3-propanediamine-N,N′-diacetato-N,N′-di-3- propionato)cobaltate(III) trihydrate, trans(O<inf>5</inf>O<inf>6</inf>)-K[Co(1, 3-pddadp)]·3H<inf>2</inf>O, stabilized by ionic, hydrogen bond and C=O dipolar interactionscitations
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article
Mononuclear gold(iii) complexes with l-histidine-containing dipeptides: tuning the structural and biological properties by variation of the N-terminal amino acid and counter anion
Abstract
<p>Gold(iii) complexes with different l-histidine-containing dipeptides, [Au(Gly-l-His-N<sub>A</sub>,N<sub>P</sub>,N3)Cl]Cl·3H<sub>2</sub>O (1a), [Au(Gly-l-His-N<sub>A</sub>,N<sub>P</sub>,N3)Cl]NO<sub>3</sub>·1.25H<sub>2</sub>O (1b), [Au(l-Ala-l-His-N<sub>A</sub>,N<sub>P</sub>,N3)Cl][AuCl<sub>4</sub>]·H<sub>2</sub>O (2a), [Au(l-Ala-l-His-N<sub>A</sub>,N<sub>P</sub>,N3)Cl]NO<sub>3</sub>·2.5H<sub>2</sub>O (2b), [Au(l-Val-l-His-N<sub>A</sub>,N<sub>P</sub>,N3)Cl]Cl·2H<sub>2</sub>O (3), [Au(l-Leu-l-His-N<sub>A</sub>,N<sub>P</sub>,N3)Cl]Cl (4a) and [Au(l-Leu-l-His-N<sub>A</sub>,N<sub>P</sub>,N3)Cl][AuCl<sub>4</sub>]·H<sub>2</sub>O (4b), have been synthesized and structurally characterized by spectroscopic (<sup>1</sup>H NMR, IR and UV-vis) and single-crystal X-ray diffraction techniques. The antimicrobial efficiency of these gold(iii) complexes, along with K[AuCl<sub>4</sub>] and the corresponding dipeptides, was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and fungi, displaying their moderate inhibiting activity. Moreover, the cytotoxic properties of the investigated complexes were assessed against the normal human lung fibroblast cell line (MRC5) and two human cancer, cervix (HeLa) and lung (A549) cell lines. None of the complexes exerted significant cytotoxic activity; nevertheless complexes that did show selectivity in terms of cancer vs. normal cell lines (2a/b and 4a/b) have been evaluated using zebrafish (Danio rerio) embryos for toxicity and antiangiogenic potential. Although the gold(iii) complexes achieved an antiangiogenic effect comparable to the known angiogenic inhibitors auranofin and sunitinib malate at 30-fold higher concentrations, they had no cardiovascular side effects, which commonly accompany auranofin and sunitinib malate treatment. Finally, binding of the gold(iii) complexes to the active sites of both human and bacterial (Escherichia coli) thioredoxin reductases (TrxRs) was demonstrated by conducting a molecular docking study, suggesting that the mechanism of biological action of these complexes can be associated with their interaction with the TrxR active site.</p>