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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Flak, Dorota Katarzyna
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (4/4 displayed)
- 2019Fluorescein ether-ester dyes for labeling of fluorinated methacrylate nanoparticlescitations
- 2018Silver and ultrasmall iron oxides nanoparticles in hydrocolloids: Effect of magnetic field and temperature on self-organizationcitations
- 2018GQDs-MSNs nanocomposite nanoparticles for simultaneous intracellular drug delivery and fluorescent imagingcitations
- 2015Tuning the photodynamic efficiency of TiO<inf>2</inf> nanotubes against HeLa cancer cells by Fe-dopingcitations
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article
Tuning the photodynamic efficiency of TiO<inf>2</inf> nanotubes against HeLa cancer cells by Fe-doping
Abstract
<p>In this study Fe-doped TiO<sub>2</sub> (0.35 to 3.50 wt% Fe) nanotubes (NTs) were prepared as the potential photosensitizer for near-visible light driven photodynamic therapy (PDT) against cervical cancer cells (HeLa). Characterization of the prepared nanotubes by X-ray diffraction (XRD), Raman spectroscopy and X-ray photoelectron spectroscopy (XPS) confirmed the successful incorporation of Fe<sup>3+</sup> as a dopant into the TiO<sub>2</sub> matrix, which was mainly composed of an anatase phase, while elemental mapping using energy dispersive X-ray spectroscopy (EDX) showed homogenous distribution of the dopant ions in TiO<sub>2</sub> for both low and high doping levels. UV-Vis studies showed that Fe doping in TiO<sub>2</sub> increases the light absorption within the visible range, particularly in the case of 0.70 and 1.40 wt% Fe-TiO<sub>2</sub> and provides additional energy levels within the band gap, which promotes the photo-excited charge transport towards the conduction band. Photo-cytotoxic activity of the prepared Fe-doped TiO<sub>2</sub> NTs was investigated in vitro against cervical cancer cells (HeLa) and compared with human normal fibroblasts (GM07492). Fe-doped TiO<sub>2</sub> NTs exhibited no or lower dark cytotoxicity than un-doped TiO<sub>2</sub> NTs, which confirms their superior biocompatibility. Under the near-visible light irradiation (∼405 nm) Fe-doped TiO<sub>2</sub> NTs showed higher photo-cytotoxic efficiency than un-doped TiO<sub>2</sub> NTs, which was found to be dependent on the NTs concentration, but not on the incubation time of cells after near-visible light irradiation. The highest activity was observed for 0.70 and 1.40 wt% Fe-TiO<sub>2</sub> NTs. Fluorescent labeling of treated HeLa cells showed distinct morphological changes, particularly in the perimitochondrial area suggesting a mitochondria-involved apoptosis of cells, but also the nuclei and cytoskeleton were subject to Fe-TiO<sub>2</sub> NTs induced photo-damage. Apoptosis of PDT treated HeLa cells was also confirmed using ethidium homodimer (EthD-1).</p>