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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Cidade, Maria Teresa
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2020Effects of polypropylene fibers and measurement methods on the yield stress of grouts for the consolidation of heritage masonry wallscitations
- 2020Yield Stress in Injection Grouts for Strengthening of Stone Masonry Wallscitations
- 2020Preliminary insights into electro-sensitive ecolubricants: A comparative analysis based on nanocelluloses and nanosilicates in castor oilcitations
- 2019Advances in Experimental and Computational Rheology
- 2019Experimental assessment of geopolymer grouts for stone masonry strengtheningcitations
- 2019Electrorheological behaviour of suspensions in silicone oil of doped polyaniline nanostructures containing carbon nanoparticlescitations
- 2017Experimental characterization of injection grouts incorporating hydrophobic silica fumecitations
- 2017Electrorheological behavior of suspensions of camphorsulfonic acid (CSA) doped polyaniline nanofibers in silicone oilcitations
- 2016Tribological behaviour of novel chemically modified biopolymer-thickened lubricating greases investigated in a steel-steel rotating ball-on-three plates tribology cellcitations
- 2015Experimental study and modeling of rheological and mechanical properties of NHL groutscitations
- 2014Polyurea dendrimer for efficient cytosolic siRNA deliverycitations
- 2014Electrorheological properties of polyaniline-vanadium oxide nanostructures suspended in silicone oilcitations
- 2013Biomimetic adhesives
- 2013Preparation and characterization of cellulose nanocomposite hydrogels as functional electrolytescitations
- 2012PVT and oscillatory tests to analyze pressure effects on polypropylene/Rodrun LC3000 blends: Determination of the pressure dependency of the viscositycitations
- 2008Experimental results for the rheological and rheo-optical behavior of poly(ethylene terephthalate)/liquid-crystalline polymer blendscitations
- 2007Influence of processing conditions on the morphological and mechanical properties of compatibilized PP/LCP blendscitations
- 2007Influence of processing conditions on the morphological development and final mechanical properties of PP/LCP blendscitations
- 2006Uniaxial extensional flow behavior of immiscible and compatibilized polypropylene/liquid crystalline polymer blendscitations
- 2005Influence of type of compatibilizer on the rheological and mechanical behavior of LCP/TP blends under different stationary and nonstationary shear conditionscitations
- 2004Evolution of morphological and rheological properties along the extruder length for blends of a commercial liquid crystalline polymer and polypropylenecitations
Places of action
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article
Polyurea dendrimer for efficient cytosolic siRNA delivery
Abstract
The design of small interfering RNA (siRNA) delivery materials showing efficacy in vivo is at the forefront of nanotherapeutics research. Polyurea (PURE-type) dendrimers are ‘smart’ biocompatible 3D polymers that unveil a dynamic and elegant back-folding mechanism involving hydrogen bonding between primary amines at the surface and tertiary amines and ureas at the core. Similarly, to a biological proton pump, they are able to automatically and reversibly transform their conformation in response to pH stimulus. Here, we show that PURE-G4 is a useful gene silencing platform showing no cellular toxicity. As a proof of concept we investigated the PURE-G4-siRNA dendriplex, which was shown to be an attractive platform with high transfection efficacy. The simplicity associated with the complexation of siRNA with polyurea dendrimers makes them a powerful tool for efficient cytosolic siRNA delivery. ; We acknowledge LabRMN at FCT/UNL and Rede Nacional de RMN for access to the facilities. Rede Nacional is supported with funds from Fundação para a Ciência e a Tecnologia (FC&T, Lisbon), Projecto de Re-equipamento Científico, Portugal. We thank the financial support from FC&T through Strategic Projects PEst-C/CTM/LA0025/2013, PEst-OE/SAU/UI0009/2013 and PEst-C/EQB/LA0006/2013 (FC&T: financial support to CENIMAT/I3N, CIGMH and REQUIMTE) and projects PTDC/EQU-EQU/116097/2009, PTDC/BBB-NAN/1812/2012, PTDC/CTM/099452/2008, PhD grants SFRH/BD/66858/2009 (R.B.R.) and SFRH/BD/62957/2009 (J.C.). ; Peer reviewed