| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Mann, Stephen
University of Bristol
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (25/25 displayed)
- 2020Mixed liposomes containing gram-positive bacteria lipidscitations
- 2017Self-Assembly of Colloidal Nanocomposite Hydrogels Using 1D Cellulose Nanocrystals and 2D Exfoliated Organoclay Layerscitations
- 2015Multimodal Plasmonics in Fused Colloidal Networkscitations
- 2014In situ X-ray reflectivity studies of molecular and molecular-cluster intercalation within purple membrane filmscitations
- 2014In situ X-ray reflectivity studies of molecular and molecular-cluster intercalation within purple membrane filmscitations
- 2014Molecular dynamics simulations reveal a dielectric-responsive coronal structure in protein-polymer surfactant hybrid nanoconstructscitations
- 2013Electrochemical crystallization of spatially organized copper microwire arrays within biomineralized (dentine) templatescitations
- 2013Apoferritin-encapsulated PbS quantum dots significantly inhibit growth of colorectal carcinoma cellscitations
- 2013Apoferritin-encapsulated PbS quantum dots significantly inhibit growth of colorectal carcinoma cellscitations
- 2013Directing Chondrogenesis of Stem Cells with Specific Blends of Cellulose and Silkcitations
- 2013The reinforcement effects of graphene oxide nanoplatelets on the mechanical and viscoelastic properties of natural rubber
- 2012High magnetic field quantum transport in Au nanoparticle-cellulose filmscitations
- 2012Polymer/nucleotide droplets as bio-inspired functional micro-compartmentscitations
- 2012The differential effect of apoferritin-PbS nanocomposites on cell cycle progression in normal and cancerous cellscitations
- 2011Lamellar nanocomposite films of purple membrane and poly(acrylate)
- 2011Guest-Molecule-Directed Assembly of Mesostructured Nanocomposite Polymer/Organoclay Hydrogelscitations
- 2011Supramolecular hydrogels derived from silver ion-mediated self-assembly of 5 '-guanosine monophosphatecitations
- 2010Assembly of poly(methacrylate)/purple membrane lamellar nanocomposite films by intercalation and in situ polymerisationcitations
- 2009Structure and Properties of Silicified Purple Membrane Thin Filmscitations
- 2009Hydroxyapatite pattern formation in PVA gelscitations
- 2009Membrane stabilization and transformation in organoclay-vesicle hybrid constructscitations
- 2009Immobilisation and encapsulation of functional protein-inorganic constructscitations
- 2007Bio-functional mesolamellar nanocomposites based on inorganic/polymer intercalation in purple membrane (bacteriorhodopsin) filmscitations
- 2007Biomimetic hydroxyapatite-drug nanocrystals as potential bone substitutes with antitumor drug delivery propertiescitations
- 2007Influence of polymer co-intercalation on guest release from aminopropyl-functionalized magnesium phyllosilicate mesolamellar nanocompositescitations
Places of action
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article
Apoferritin-encapsulated PbS quantum dots significantly inhibit growth of colorectal carcinoma cells
Abstract
Colorectal carcinoma (CRC) is the 3 rd most common cancer worldwide, thus development of novel therapeutic strategies is imperative. Herein potent, selective dose-dependent antitumor activity of horse spleen apoferritin encapsulated PbS quantum dots (AFt-PbS) against two human-derived colorectal carcinoma cell lines is reported (GI 50 ∼ 70 μg mL -1 ). Following in vitro exposure to AFt-PbS, CRC cells fail to recover proliferative capacity, and undergo apoptosis triggered by the generation of reactive oxygen species (ROS). In stark contrast, the AFt-PbS nanocomposites do not affect the growth and cell cycle of non-tumor human microvessel endothelial HMEC-1 cells (GI 50 > 500 μg mL -1 ). In vivo, AFt-PbS QDs are well tolerated by mice. Neither adverse health nor behavioral indicators were observed throughout the 15 day study. The photoluminescence of AFt-PbS combined with selective antitumor activity offer potential development of AFt-PbS for simultaneous non-invasive imaging and treatment of malignant tissue. This journal is