| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Hofe, Thorsten
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (1/1 displayed)
Places of action
| Organizations | Location | People |
|---|
article
Modular design of glyco-microspheres via mild pericyclic reactions and their quantitative analysis
Abstract
The facile and efficient functionalization of porous poly(glycidyl methacrylate) (pGMA) microspheres via hetero Diels-Alder (HDA) chemistry with poly(3-O-acryloyl-1,2: 5,6-di-O-isopropylidene-alpha-D-glucofuranoside) (pAIpGlc) prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization employing electron deficient thiocarbonylthio compounds (benzyl pyridin-2-yldithioformate (BPDF)) is described in detail. The efficiency of the employed ‘grafting to' approach is qualitatively and quantitatively analyzed. Initially the microspheres are functionalized with a highly reactive diene - cyclopentadiene (Cp) - in one step with sodium cyclopentadienide, and subsequently reacted with a protected glycopolymer (number-average molecular weight, M-n = 4200 g mol(-1); polydispersity index, PDI = 1.2) that carries a thiocarbonyl moiety functioning as a dienophile. The functionalization of the microspheres is achieved under mild conditions (T = 50 degrees C) with trifluoroacetic acid (TFA) as a readily removable catalyst. Deprotection of the grafted pAIpGlc to poly(3-O-acryloyl-alpha,beta-D-glucopyranoside) (pAGlc) can be performed after functionalization in one pot with formic acid at ambient temperature. The obtained loading capacity is 2.63 x 10(19) chains per g and the grafting density is close to 0.16 chains per nm(2). Quantitative analysis of the grafting densities is achieved via elemental analysis; the pore size distribution before functionalization was analyzed by inverse size exclusion chromatography (iSEC). Further employed characterization techniques include scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) and high resolution attenuated total reflectance (ATR) FT-IR microscopy supporting the successful modification of the microspheres.