| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Klajnert-Maculewicz, Barbara
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (16/16 displayed)
- 2023Dendrimersomes: Biomedical applicationscitations
- 2020Poly(lysine) Dendrimers Form Complexes with siRNA and Provide Its Effcient Uptake by Myeloid Cells: Model Studies for Therapeutic Nucleic Acid Delivery
- 2020Glucose-modified carbosilane dendrimers: Interaction with model membranes and human serum albumincitations
- 2020Poly(lysine) Dendrimers Form Complexes with siRNA and Provide Its Ecient Uptake by Myeloid Cells: Model Studies for Therapeutic Nucleic Acid Deliverycitations
- 2019Pyrrolidone-modified PAMAM dendrimers enhance anti-inflammatory potential of indomethacin in vitrocitations
- 2019PAMAM and PPI Dendrimers in Biophysical and Thermodynamic Studies on the Delivery of Therapeutic Nucleotides, Nucleosides and Nucleobase Derivatives for Anticancer Applicationcitations
- 2019Non-Traditional Intrinsic Luminescence (NTIL): Dynamic Quenching Demonstrates the Presence of Two Distinct Fluorophore Types Associated with NTIL Behavior in Pyrrolidone-Terminated PAMAM Dendrimerscitations
- 2017Dendrimers as nanocarriers for nucleoside analoguescitations
- 2017Dendrimers for fluorescence-based bioimagingcitations
- 2017Cationic Phosphorus Dendrimer Enhances Photodynamic Activity of Rose Bengal against Basal Cell Carcinoma Cell Linescitations
- 2016Fourier transform infrared spectroscopy (FTIR) characterization of the interaction of anti-cancer photosensitizers with dendrimerscitations
- 2015Anticancer siRNA cocktails as a novel tool to treat cancer cells. Part (B). Efficiency of pharmacological actioncitations
- 2013Dendrimers in Biomedical Applicationscitations
- 2013Dendrimers as Antiamyloidogenic Agents. Dendrimer-amyloid Aggregates Morphology and Cell Toxicitycitations
- 2013Characterization of Dendrimers and Their Interactions with Biomolecules for Medical use by Means of Electron Magnetic Resonancecitations
- 2013Natural and Synthetic Biomaterials as Composites of Advanced Drug Delivery Nano Systems (ADDNSS). Biomedical Applicationscitations
Places of action
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booksection
Characterization of Dendrimers and Their Interactions with Biomolecules for Medical use by Means of Electron Magnetic Resonance
Abstract
The studies presented in this report arise from collaborations in the framework of the COST action TD0802. We used both the spin label and the spin probe techniques in order to characterize the dendrimers and their interactions with biomolecules by means of a computer aided analysis of the electron paramagnetic resonance (EPR) spectra. First, we characterized different dendrimers by analysing the complexes formed with Cu2+ in water solutions in different experimental conditions. The oligosaccharide shell of glycodendrimers affects both the internal and external metal ion complexation providing axial and rhombic geometries. Anionic carbosilane dendrimers are able to selectively coordinate copper ions at the dendrimer internal/external surface, depending on generation and functionalization with sulfate or carboxylate groups. Amine‐functionalized dendrons with cholesterol groups at the focal point were also characterized for their structure and interacting ability, but we also analysed the aggregates formed by the self‐assembling dendrons using spin probes able to insert into the hydrophobic domain. Surfactant spin probes were also used to study the encapsulation of dendrimers into lamellar, cubic and hexagonal lyotropic liquid crystals (LLCs) as drug delivery systems. Finally, we used EPR probes to monitor the formation of amyloid and prion fibrils, responsible of neurodegenerative diseases, and the role of different dendrimers to prevent the fibril formation. The aggregation behavior over time was analyzed in the absence and presence of phosphorous dendrimers and glycodendrimers thus providing precious information on the kinetics of aggregation and the type of interactions occurring in the system.