| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Mata, F. Javier De La
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2023Removing lead from water with carboxylate dendrimers and magnetic nanoparticles modified with carboxylate dendrimerscitations
- 2023Ruthenium metallodendrimer against triple-negative breast cancer in micecitations
- 2023Combination of Copper Metallodendrimers with Conventional Antitumor Drugs to Combat Cancer in In Vitro Modelscitations
- 2023Lipid-coated ruthenium dendrimer conjugated with doxorubicin in anti-cancer drug delivery: Introducing protocolscitations
- 2023Carbosilane ruthenium metallodendrimer as alternative anti-cancer drug carrier in triple negative breast cancer mouse model: A preliminary studycitations
- 2021Organometallic dendrimers based on Ruthenium(II) N-heterocyclic carbenes and their implication as delivery systems of anticancer small interfering RNAcitations
- 2020Fine-Tuning the Interaction and Therapeutic Effect of Cu(II) Carbosilane Metallodendrimers in Cancer Cells: An In Vitro Electron Paramagnetic Resonance Studycitations
- 2014Synthesis of new amphiphilic water‐stable hyperbranched polycarbosilane polymerscitations
- 2013Characterization of Dendrimers and Their Interactions with Biomolecules for Medical use by Means of Electron Magnetic Resonancecitations
- 2004Tris(pyrazolyl)borate carbosilane dendrimers and metallodendrimerscitations
Places of action
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booksection
Characterization of Dendrimers and Their Interactions with Biomolecules for Medical use by Means of Electron Magnetic Resonance
Abstract
The studies presented in this report arise from collaborations in the framework of the COST action TD0802. We used both the spin label and the spin probe techniques in order to characterize the dendrimers and their interactions with biomolecules by means of a computer aided analysis of the electron paramagnetic resonance (EPR) spectra. First, we characterized different dendrimers by analysing the complexes formed with Cu2+ in water solutions in different experimental conditions. The oligosaccharide shell of glycodendrimers affects both the internal and external metal ion complexation providing axial and rhombic geometries. Anionic carbosilane dendrimers are able to selectively coordinate copper ions at the dendrimer internal/external surface, depending on generation and functionalization with sulfate or carboxylate groups. Amine‐functionalized dendrons with cholesterol groups at the focal point were also characterized for their structure and interacting ability, but we also analysed the aggregates formed by the self‐assembling dendrons using spin probes able to insert into the hydrophobic domain. Surfactant spin probes were also used to study the encapsulation of dendrimers into lamellar, cubic and hexagonal lyotropic liquid crystals (LLCs) as drug delivery systems. Finally, we used EPR probes to monitor the formation of amyloid and prion fibrils, responsible of neurodegenerative diseases, and the role of different dendrimers to prevent the fibril formation. The aggregation behavior over time was analyzed in the absence and presence of phosphorous dendrimers and glycodendrimers thus providing precious information on the kinetics of aggregation and the type of interactions occurring in the system.