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Thambiliyagodage, Charitha
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article
In vitro influence of PEG functionalized ZnO–CuO nanocomposites on bacterial growth
Abstract
<jats:title>Abstract</jats:title><jats:p>Polyethyleneglycol-coated biocompatible CuO–ZnO nanocomposites were fabricated hydrothermally varying Zn:Cu ratios as 1:1, 2:1, and 1:2, and their antibacterial activity was determined through the well diffusion method against the Gram-negative <jats:italic>Escherichia coli</jats:italic><jats:bold><jats:italic>,</jats:italic></jats:bold><jats:italic> Pseudomonas aeruginosa</jats:italic>, <jats:italic>Klebsiella pneumoniae,</jats:italic> and the Gram-positive <jats:italic>Staphylococcus aureus.</jats:italic> The minimum inhibitory concentration and the minimum bactericidal concentration values of the synthesized samples were determined. Subsequently, the time synergy kill assay was performed to elucidate the nature of the overall inhibitory effect against the aforementioned bacterial species. The mean zone of inhibition values for all four samples are presented. The inhibitory effect increased with increasing concentration of the nanocomposite (20, 40 and 60 mg/ml) on all the bacterial species except for <jats:italic>S. aureus</jats:italic>. According to the MBC/MIC ratio, ZnO was found to be bacteriostatic for <jats:italic>E. coli</jats:italic> and <jats:italic>P. aeruginosa,</jats:italic> and bactericidal for <jats:italic>S. aureus</jats:italic> and <jats:italic>K. pneumoniae</jats:italic>. Zn:Cu 2:1 was bactericidal on all bacterial species. A bacteriostatic effect was observed on <jats:italic>E. coli</jats:italic> and <jats:italic>P. aeruginosa</jats:italic> in the presence of Zn:Cu 1:1 whereas, it showed a bactericidal effect on <jats:italic>S. aureus</jats:italic> and <jats:italic>K. pneumoniae.</jats:italic> Zn:Cu 1:2 exhibited a bacteriostatic effect on <jats:italic>E. coli</jats:italic> while a bactericidal effect was observed for <jats:italic>E. coli, P. aeruginosa,</jats:italic> and <jats:italic>K. pneumoniae.</jats:italic> The metal oxide nanocomposites were found to be more sensitive towards the Gram-positive strain than the Gram-negative strains<jats:italic>.</jats:italic> Further, all the nanocomposites possess anti-oxidant activity as shown by the DPPH assay.</jats:p>