Materials Map

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (1/1 displayed)

  • 2021Retrospective observational study of HER2 immunohistochemistry in borderline breast cancer patients undergoing neoadjuvant therapy, with an emphasis on Group 2 (HER2/CEP17 ratio ≥2.0, HER2 copy number <4.0 signals/cell) cases17citations

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Ellis, Ian
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Rakha, Emad
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Gallagy, Grace
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Murray, Ciara
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Provenzano, Elena
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Katayama, Ayaka
1 / 1 shared
Tanchel, Bruce
1 / 1 shared
Eldib, Karim
1 / 1 shared
Badr, Nahla
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Marchiò, Caterina
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Toss, Michael S.
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Quinn, Cecily M.
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Walshe, Janice
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2021

Co-Authors (by relevance)

  • Ellis, Ian
  • Rakha, Emad
  • Gallagy, Grace
  • Murray, Ciara
  • Provenzano, Elena
  • Katayama, Ayaka
  • Tanchel, Bruce
  • Eldib, Karim
  • Badr, Nahla
  • Marchiò, Caterina
  • Toss, Michael S.
  • Quinn, Cecily M.
  • Walshe, Janice
  • Shaaban, Abeer
  • Lee, Andrew H. S.
  • Purnell, Dave
  • Purdie, Colin
  • Millican-Slater, Rebecca
OrganizationsLocationPeople

article

Retrospective observational study of HER2 immunohistochemistry in borderline breast cancer patients undergoing neoadjuvant therapy, with an emphasis on Group 2 (HER2/CEP17 ratio ≥2.0, HER2 copy number <4.0 signals/cell) cases

  • Ellis, Ian
  • Rakha, Emad
  • Gallagy, Grace
  • Murray, Ciara
  • Provenzano, Elena
  • Katayama, Ayaka
  • Tanchel, Bruce
  • Eldib, Karim
  • Badr, Nahla
  • Marchiò, Caterina
  • Toss, Michael S.
  • Miligy, Islam M.
  • Quinn, Cecily M.
  • Walshe, Janice
  • Shaaban, Abeer
  • Lee, Andrew H. S.
  • Purnell, Dave
  • Purdie, Colin
  • Millican-Slater, Rebecca
Abstract

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The ASCO/CAP guidance on HER2 testing in breast cancer (BC) has recently changed. Group 2 tumours with immunohistochemistry score 2+ and <jats:italic>HER2</jats:italic>/<jats:italic>CEP17</jats:italic> ratio ≥2.0 and <jats:italic>HER2</jats:italic> copy number &lt;4.0 signals/cell were re-classified as HER2 negative. This study aims to examine the response of Group 2 tumours to neoadjuvant chemotherapy (NACT).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>749 BC cases were identified from 11 institutions. The association between HER2 groups and pathological complete response (pCR) was assessed.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>54% of immunohistochemistry HER2 positive (score 3+) BCs showed pCR, compared to 19% of immunohistochemistry 2+ FISH amplified cases. 27% of Group 2 treated with HER2 targeted therapy achieved pCR, compared to 19 and 11% in the combined Groups 1 + 3 and Groups 4 + 5, respectively. No difference in pCR rates was identified between Group 2 and Group 1 or combined Groups 1 + 3. However, Group 2 response rate was higher than Groups 4 + 5 (<jats:italic>p</jats:italic> = 0.017).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>No difference in pCR was detected in tumours with a <jats:italic>HER2/</jats:italic>CEP17 ratio ≥2.0 and a HER2 score 2+ by IHC when stratified by <jats:italic>HER2</jats:italic> gene copy number. Our data suggest that ASCO/CAP HER2 Group 2 carcinomas should be evaluated further with respect to eligibility for HER2 targeted therapy.</jats:p></jats:sec>

Topics
  • size-exclusion chromatography