| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Duda, Georg N.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (14/14 displayed)
- 2020In Vivo Validation of Spray-Dried Mesoporous Bioactive Glass Microspheres Acting as Prolonged Local Release Systems for BMP-2 to Support Bone Regenerationcitations
- 2018Correlations between nanostructure and micromechanical properties of healing bonecitations
- 2018Dosage and composition of bioactive glasses differentially regulate angiogenic and osteogenic response of human MSCscitations
- 2017Combining Coherent Hard X-Ray Tomographies with Phase Retrieval to Generate Three-Dimensional Models of Forming Bonecitations
- 2017Scaffold curvature-mediated novel biomineralization process originates a continuous soft tissue-to-bone interfacecitations
- 2017Multiscale characterization of the mineral phase at skeletal sites of breast cancer metastasiscitations
- 2015Effect of in vivo loading on bone composition varies with animal agecitations
- 2015High resolution 3D laboratory x-ray tomography data of femora from young, 1-14 day old C57BL/6 micecitations
- 2015Registering 2D and 3D imaging data of bone during healingcitations
- 2015Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formationcitations
- 2014Mechanical and structural properties of bone in non-critical and critical healing in ratcitations
- 2014Relationship between nanoscale mineral properties and calcein labeling in mineralizing bone surfacescitations
- 2011Poorly Ordered Bone as an Endogenous Scaffold for the Deposition of Highly Oriented Lamellar Tissue in Rapidly Growing Ovine Bonecitations
- 2002Mechanical conditions in the internal stabilization of proximal tibial defectscitations
Places of action
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article
Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation
Abstract
The effectiveness of stem cell therapies has been hampered by cell death and limited control over fate. These problems can be partially circumvented by using macroporous biomaterials that improve the survival of transplanted stem cells and provide molecular cues to direct cell phenotype. Stem cell behaviour can also be controlled in vitro by manipulating the elasticity of both porous and non-porous materials, yet translation to therapeutic processes in vivo remains elusive. Here, by developing injectable, void-forming hydrogels that decouple pore formation from elasticity, we show that mesenchymal stem cell (MSC) osteogenesis in vitro, and cell deployment in vitro and in vivo, can be controlled by modifying, respectively, the hydrogel's elastic modulus or its chemistry. When the hydrogels were used to transplant MSCs, the hydrogel's elasticity regulated bone regeneration, with optimal bone formation at 60 kPa. Our findings show that biophysical cues can be harnessed to direct therapeutic stem cell behaviours in situ.