Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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Materials Map under construction

The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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1.080 Topics available

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977 Locations available

693.932 PEOPLE
693.932 People People

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Naji, M.
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Hinrichs, Wouter

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University of Groningen

in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (17/17 displayed)

  • 2024Combinations of arginine and pullulan reveal the selective effect of stabilization mechanisms on different lyophilized proteins1citations
  • 2018The mechanism behind the biphasic pulsatile drug release from physically mixed poly(DL-lactic(-co-glycolic) acid)-based compacts17citations
  • 2016Compacted Solid Dosage Formcitations
  • 2015Protein release from water-swellable poly(d,l-lactide-PEG)-b-poly(ϵ-caprolactone) implants9citations
  • 2015Protein Stability during Hot Melt Extrusioncitations
  • 2015Size and molecular flexibility of sugars determine the storage stability of freeze-dried proteins120citations
  • 2015Protein Stability during Hot Melt Extrusion: The Effect of Extrusion Temperature, Hydrophilicity of Polymers and Sugar Glass Pre-stabilizationcitations
  • 2015Polymeric formulations for drug release prepared by hot melt extrusion107citations
  • 2013Designing CAF-adjuvanted dry powder vaccines35citations
  • 2013Unraveling protein stabilization mechanisms151citations
  • 2012Preparation and physicochemical evaluation of a new tacrolimus tablet formulation for sublingual administration13citations
  • 2010Effect of drug-carrier interaction on the dissolution behavior of solid dispersion tablets24citations
  • 2006Characterization of the molecular distribution of drugs in glassy solid dispersions at the nano-meter scale, using differential scanning calorimetry and gravimetric water vapour sorption techniques130citations
  • 2005Inulin is a promising cryo- and lyoprotectant for PEGylated lipoplexes73citations
  • 2004Incorporation of lipophilic drugs in sugar glasses by lyophilization using a mixture of water and tertiary butyl alcohol as solvent66citations
  • 2003Investigations into the stabilization of drugs by sugar glasses31citations
  • 2001Inulin glasses for the stabilization of therapeutic proteins156citations

Places of action

Chart of shared publication
Frijlink, Henderik W.
16 / 32 shared
Lasorsa, Alessia
1 / 1 shared
Nguyen, Trung Truong Khanh
1 / 1 shared
Zillen, Daan
1 / 2 shared
Grasmeijer, Niels
2 / 3 shared
Beugeling, Max
1 / 2 shared
Born, Philip A.
1 / 2 shared
Amssoms, Katie
1 / 2 shared
Baert, Lieven
1 / 2 shared
Meulen, Merel Van Der
1 / 1 shared
Schwengle, Kevin
1 / 2 shared
Amssoms, Katie Ingrid Eduard
1 / 1 shared
Baert, Lieven Elvire Colette
1 / 1 shared
Zuidema, Johan
1 / 1 shared
Steendam, Rob
1 / 1 shared
Hiemstra, Christine
1 / 1 shared
Waard, Hans De
1 / 1 shared
Stanković, Milica
2 / 3 shared
Olinga, Peter
2 / 2 shared
Teekamp, Naomi
2 / 2 shared
Tonnis, W. F.
1 / 1 shared
Mensink, M. A.
1 / 1 shared
Jager, A. De
1 / 1 shared
Rantanen, Jukka
1 / 43 shared
Ingvarsson, Pall Thor
1 / 2 shared
Schmidt, Signe Tandrup
1 / 1 shared
Christensen, Dennis
1 / 1 shared
Larsen, Niels Bent
1 / 22 shared
Foged, Camilla
1 / 8 shared
Yang, Mingshi
1 / 7 shared
Nielsen, Hanne Morck
1 / 1 shared
Andersen, Peter
1 / 3 shared
Stankovic, M.
1 / 1 shared
Waard, H. De
1 / 1 shared
Grasmeijer, N.
1 / 1 shared
Pham, Bao T.
1 / 1 shared
Holen, Maru
1 / 1 shared
Plas, Afke Van Der
1 / 1 shared
Schellekens, Reinout C. A.
1 / 1 shared
Srinarong, Parinda
2 / 2 shared
Visser, Marinella R.
1 / 1 shared
Kouwen, Sander
1 / 1 shared
Visser, M. R.
1 / 1 shared
Drooge, D. J. Van
2 / 2 shared
Smedt, S. C. De
1 / 1 shared
Sanders, N. N.
1 / 1 shared
Demeester, J.
1 / 2 shared
Jong, Gerhardus J. De
1 / 1 shared
Somsen, Govert W.
1 / 3 shared
Eriksson, Jonas H. C.
1 / 2 shared
Prinsen, M. G.
1 / 1 shared
Chart of publication period
2024
2018
2016
2015
2013
2012
2010
2006
2005
2004
2003
2001

Co-Authors (by relevance)

  • Frijlink, Henderik W.
  • Lasorsa, Alessia
  • Nguyen, Trung Truong Khanh
  • Zillen, Daan
  • Grasmeijer, Niels
  • Beugeling, Max
  • Born, Philip A.
  • Amssoms, Katie
  • Baert, Lieven
  • Meulen, Merel Van Der
  • Schwengle, Kevin
  • Amssoms, Katie Ingrid Eduard
  • Baert, Lieven Elvire Colette
  • Zuidema, Johan
  • Steendam, Rob
  • Hiemstra, Christine
  • Waard, Hans De
  • Stanković, Milica
  • Olinga, Peter
  • Teekamp, Naomi
  • Tonnis, W. F.
  • Mensink, M. A.
  • Jager, A. De
  • Rantanen, Jukka
  • Ingvarsson, Pall Thor
  • Schmidt, Signe Tandrup
  • Christensen, Dennis
  • Larsen, Niels Bent
  • Foged, Camilla
  • Yang, Mingshi
  • Nielsen, Hanne Morck
  • Andersen, Peter
  • Stankovic, M.
  • Waard, H. De
  • Grasmeijer, N.
  • Pham, Bao T.
  • Holen, Maru
  • Plas, Afke Van Der
  • Schellekens, Reinout C. A.
  • Srinarong, Parinda
  • Visser, Marinella R.
  • Kouwen, Sander
  • Visser, M. R.
  • Drooge, D. J. Van
  • Smedt, S. C. De
  • Sanders, N. N.
  • Demeester, J.
  • Jong, Gerhardus J. De
  • Somsen, Govert W.
  • Eriksson, Jonas H. C.
  • Prinsen, M. G.
OrganizationsLocationPeople

article

Investigations into the stabilization of drugs by sugar glasses

  • Jong, Gerhardus J. De
  • Frijlink, Henderik W.
  • Somsen, Govert W.
  • Hinrichs, Wouter
  • Eriksson, Jonas H. C.
Abstract

<p>PURPOSE: To study the effect of the high-pH buffers ammediol, borax, CHES, TRIS, and Tricine on the glass transition temperature of the freeze concentrated fraction (Tg') of trehalose/buffer and inulin/buffer solutions at pH 6.0 and pH 9.8. Also, the glass transition temperature (Tg) of sugar glasses obtained after freeze drying of these solutions was elucidated. Additionally, the effect occurring during the freezing process on the pH of the various buffers was investigated. Furthermore, the stability of alkaline phosphatase (AP) incorporated in these sugar glasses prepared from solutions at pH 9.8 was evaluated.</p><p>METHODS: The Tg' and Tg were measured using differential scanning calorimetry (DSC), and the change of pH during freezing was estimated by using an indicator solution added to the respective solutions. The enzymatic activity of AP after freeze drying and storage at 60 degrees C was evaluated by an enzymatic activity assay.</p><p>RESULTS: It was found that the Tg' and Tg of the samples investigated are strongly influenced by the presence of the buffer. On freezing, only minor changes of the pH were observed. The samples with the lowest Tg and the samples containing buffers that formed complexes with the sugars showed the poorest stability of the AP.</p><p>CONCLUSIONS: The stabilizing capacities of sugars that are currently recognized as excellent stabilizers for proteins during drying and storage can be completely lost if certain high-pH buffers such as ammediol, borax, and TRIS are used at high concentrations. Loss of stabilizing capacities can be ascribed to strong depression of the Tg' and Tg or to complex formation.</p>

Topics
  • glass
  • glass
  • thermogravimetry
  • glass transition temperature
  • differential scanning calorimetry
  • drying