| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Langer, Robert
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (9/9 displayed)
- 2024Monomer centred selectivity guidelines for sulfurated ring-opening copolymerisations
- 2024Monomer centred selectivity guidelines in sulfurated ring-opening copolymerisations
- 2022Unique design approach to realize an O-band laser monolithically integrated on 300 mm Si substrate by nano-ridge engineeringcitations
- 2014Ionizable Amphiphilic Dendrimer‐Based Nanomaterials with Alkyl‐Chain‐Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivocitations
- 2009Partial least squares regression as a powerful tool for investigating large combinatorial polymer librariescitations
- 2009<i>In vitro</i> and <i>in vivo</i> degradation of poly(1,3‐diamino‐2‐hydroxypropane‐<i>co</i>‐polyol sebacate) elastomerscitations
- 2008Microfluidic platform for controlled synthesis of polymeric nanoparticlescitations
- 2008TOF-SIMS analysis of a 576 micropatterned copolymer array to reveal surface moieties that control wettabilitycitations
- 2007Why inhaling salt water changes what we exhalecitations
Places of action
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article
Microfluidic platform for controlled synthesis of polymeric nanoparticles
Abstract
A central challenge in the development of drug-encapsulated polymeric nanoparticles is the inability to control the mixing processes required for their synthesis resulting in variable nanoparticle physicochemical properties. Nanoparticles may be developed by mixing and nanoprecipitation of polymers and drugs dissolved in organic solvents with nonsolvents. We used rapid and tunable mixing through hydrodynamic flow focusing in microfluidic channels to control nanoprecipitation of poly(lactic- co-glycolic acid)- b-poly(ethylene glycol) diblock copolymers as a model polymeric biomaterial for drug delivery. We demonstrate that by varying (1) flow rates, (2) polymer composition, and (3) polymer concentration we can optimize the size, improve polydispersity, and control drug loading and release of the resulting nanoparticles. This work suggests that microfluidics may find applications for the development and optimization of polymeric nanoparticles in the newly emerging field of nanomedicine.