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Dong, Mingdong
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Topics
Publications (8/8 displayed)
- 2022Antimicrobial and Wound-Healing Activities of Graphene-Reinforced Electrospun Chitosan/Gelatin Nanofibrous Nanocomposite Scaffoldscitations
- 2017Synthesis and characterization of O-acylated-ω-hydroxy fatty acids as skin-protecting barrier lipidscitations
- 2016Ultralong Fatty Acyl Derivatives As Occlusive Structure Lipids for Cosmetic Applicationscitations
- 2014$mathrm{(NH_{4})_{4}Sn_{2}S_{6}·3H_{2}O}$: Crystal Structure, Thermal Decomposition, and Precursor for Textured Thin Filmcitations
- 2013Electrospun UV-responsive supramolecular nanofibers from a cyclodextrin-azobenzene inclusion complexcitations
- 2010Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowthcitations
- 2010DNA-templated covalent coupling of G4 PAMAM dendrimerscitations
- 2009Self-assembly of a nanoscale DNA box with a controllable lidcitations
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article
Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowth
Abstract
Microstructured 20 μm thick polymer filaments used as nerve implants were loaded with chitosan/siRNA nanoparticles to promote nerve regeneration and ensure local delivery of nanotherapeutics. The stable nanoparticles were rapidly internalized by cells and did not affect cell viability. Target mRNA was successfully reduced by 65-75% and neurite outgrowth was enhanced even in an inhibitory environment. This work, thus, supports the application of nanobiofunctionalized implants as a novel approach for spinal cord and nerve repair.