| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Rantanen, Jukka
University of Copenhagen
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (43/43 displayed)
- 2024Leucine as a Moisture-Protective Excipient in Spray-Dried Protein/Trehalose Formulationcitations
- 2024Compaction behavior of freeze-dried and spray-dried trypsin/lactose particulate systems
- 2023Co-administration of Intravenous Drugscitations
- 2023Coating of Primary Powder Particles Improves the Quality of Binder Jetting 3D Printed Oral Solid Productscitations
- 2022Structured approach for designing drug-loaded solid products by binder jetting 3D printingcitations
- 2021Enabling formulations of aprepitantcitations
- 2020Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printingcitations
- 2020Exploring the Complexity of Processing-Induced Dehydration during Hot Melt Extrusion Using In-Line Raman Spectroscopycitations
- 2019Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparationcitations
- 2019Exploring the chemical space for freeze-drying excipientscitations
- 2019Roadmap to 3D printed oral pharmaceutical dosage formscitations
- 2018The use of molecular descriptors in the development of co-amorphous formulationscitations
- 2017Investigation of nanocarriers and excipients for preparation of nanoembedded microparticlescitations
- 2017Correlation between calculated molecular descriptors of excipient amino acids and experimentally observed thermal stability of lysozymecitations
- 2017The flow properties and presence of crystals in drug-polymer mixturescitations
- 2017The effect of poly (lactic-co-glycolic) acid composition on the mechanical properties of electrospun fibrous matscitations
- 2017The effect of poly (lactic-co-glycolic) acid composition on the mechanical properties of electrospun fibrous matscitations
- 2016Oscillatory Shear Rheology in Examining the Drug-Polymer Interactions Relevant in Hot Melt Extrusioncitations
- 2016Properties of the Sodium Naproxen-Lactose-Tetrahydrate Co-Crystal upon Processing and Storagecitations
- 2015Three-Dimensional Printing of Drug-Eluting Implantscitations
- 2015Well-plate freeze-dryingcitations
- 2015Rheology as a tool for evaluation of melt processability of innovative dosage formscitations
- 2014Evaluation of ring shear testing as a characterization method for powder flow in small-scale powder processing equipmentcitations
- 2014Near-Infrared Imaging for High-Throughput Screening of Moisture-Induced Changes in Freeze-Dried Formulationscitations
- 2013A step toward development of printable dosage forms for poorly soluble drugscitations
- 2013Interpreting the Disordered Crystal Structure of Sodium Naproxen Tetrahydratecitations
- 2013Designing CAF-adjuvanted dry powder vaccinescitations
- 2013Investigation of the phase separation of PNIPAM using infrared spectroscopy together with multivariate data analysiscitations
- 2013Fast-track to a solid dispersion formulation using multi-way analysis of complex interactionscitations
- 2013Foreign matter identification from solid dosage formscitations
- 2013Exploring the solid-form landscape of pharmaceutical hydratescitations
- 2012Complementing high-throughput X-ray powder diffraction data with quantum-chemical calculationscitations
- 2012Crystal morphology modification by the addition of tailor-made stereocontrolled poly(N-isopropyl acrylamide)citations
- 2012Atomic pairwise distribution function analysis of the amorphous phase prepared by different manufacturing routescitations
- 2011Assessment of crystalline disorder in cryo-milled samples of indomethacin using atomic pair-wise distribution functionscitations
- 2006Understanding processing-induced phase transformations in erythromycin-PEG 6000 solid dispersionscitations
- 2005Physical changes of beta-sitosterol crystals in oily suspensions during heatingcitations
- 2005IR spectroscopy together with multivariate data analysis as a process analytical tool for in-line monitoring of crystallization process and solid-state analysis of crystalline productcitations
- 2005Pellet manufacturing by extrusion-spheronization using process analytical technologycitations
- 2005Characterization of polymorphic solid-state changes using variable temperature X-ray powder diffractioncitations
- 2004Role of excipients in hydrate formation kinetics of theophylline in wet masses studied by near-infrared spectroscopycitations
- 2003Dehydration studies using a novel multichamber microscale fluid bed dryer with in-line near-infrared measurementcitations
- 2002Hydrate formation during wet granulation studied by spectroscopic methods and multivariate analysis
Places of action
| Organizations | Location | People |
|---|
article
Crystal morphology modification by the addition of tailor-made stereocontrolled poly(N-isopropyl acrylamide)
Abstract
The use of additives in crystallization of pharmaceuticals is known to influence the particulate properties critically affecting down-stream processing and the final product performance.Desired functionality can be build into these materials, e.g. via optimized synthesis of a polymeric additive.One such additive is the thermosensitive polymer, poly(N-isopropyl acrylamide) (PNIPAM).The use of PNIPAM as a crystallization additive provides a possibility to affect viscosity in separation temperatures and nucleation and growth rates in higher temperatures.In this study, novel PNIPAM derivatives consisting of both isotactic-rich and atactic blocks were used as additives in evaporative crystallization of a model compound, nitrofurantoin (NF).Special attention was paid to possible interactions between NF and PNIPAM and the aggregation state of PNIPAM as a function of temperature and solvent composition.Optical light microscopy, Raman and FTIR spectroscopy were used to investigate the structure of the NF crystals and possible interaction with PNIPAM.A drastic change in the growth mechanism of nitrofurantoin crystals as monohydrate form II (NFMH-II) was observed in the presence of PNIPAM; the morphology of crystals changed from needle to dendritic shape.Additionally, the amphiphilic nature of PNIPAM increased the solubility of nitrofurantoin in water.PNIPAMs with varying molecular weights and stereoregularities resulted in similar changes in the crystal habit of the drug regardless of whether the polymer was aggregated or not.However, with increased additive concentration slower nucleation and growth rates of the crystals were observed.Heating of the crystallization medium resulted in phase separation of the PNIPAM.The phase separation had an influence on the achieved crystal morphology resulting in fewer, visually larger and more irregular dendritic crystals.No proof of hydrogen bond formation between PNIPAM and NF was observed, and the suggested mechanism for the observed dendritic morphology is related to the steric hindrance phenomenon.PNIPAM can be used as a crystallization additive with an obvious effect on the growth of NF crystals.The structural design of PNIPAM and related viscosity changes as a function of temperature can be used to optimize nucleation, growth and separation of crystals from the crystallization medium.[on SciFinder (R)]