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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Palmans, Ara Anja
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (36/36 displayed)
- 2024Enhanced Efficiency of Pd(0)-Based Single Chain Polymeric Nanoparticles for in Vitro Prodrug Activation by Modulating the Polymer’s Microstructurecitations
- 2023Dynamic covalent networks with tunable dynamicity by mixing acylsemicarbazides and thioacylsemicarbazidescitations
- 2022Elucidating the Stability of Single-Chain Polymeric Nanoparticles in Biological Media and Living Cellscitations
- 2022Developing Pd(ii) based amphiphilic polymeric nanoparticles for pro-drug activation in complex mediacitations
- 2022Spectrally PAINTing a Single Chain Polymeric Nanoparticle at Super-Resolutioncitations
- 2021Compartmentalized Polymers for Catalysis in Aqueous Mediacitations
- 2021Consequences of Chirality in Directing the Pathway of Cholesteric Helix Inversion of π-Conjugated Polymers by Lightcitations
- 2020Long-lived charge-transfer state from B−N frustrated Lewis pairs enchained in supramolecular copolymerscitations
- 2020Tuning polymer properties of non-covalent crosslinked PDMS by varying supramolecular interaction strengthcitations
- 2019Detailed approach to investigate thermodynamically controlled supramolecular copolymerizationscitations
- 2019Detailed approach to investigate thermodynamically controlled supramolecular copolymerizations
- 2019Stereocomplexes of discrete, isotactic lactic acid oligomers conjugated with oligodimethylsiloxanescitations
- 2019Future of supramolecular copolymers unveiled by reflecting on covalent copolymerizationcitations
- 2019Equilibrium model for supramolecular copolymerizationscitations
- 2018Supramolecular block copolymers under thermodynamic controlcitations
- 2018Supramolecular block copolymers under thermodynamic control
- 2017Self-assembly of hydrogen-bonding gradient copolymerscitations
- 2017Self-assembly of hydrogen-bonding gradient copolymers:sequence control via tandem living radical polymerization with transesterificationcitations
- 2015The coil-to-globule transition of single-chain polymeric nanoparticles with a chiral internal secondary structurecitations
- 2015Modular synthetic platform for the construction of functional single-chain polymeric nanoparticles:from aqueous catalysis to photosensitizationcitations
- 2015Modular synthetic platform for the construction of functional single-chain polymeric nanoparticlescitations
- 2014Consequences of block sequence on the orthogonal folding of triblock copolymerscitations
- 2014The effect of pendant benzene-1,3,5-tricarboxamides in the middle block of ABA triblock copolymers : synthesis and mechanical propertiescitations
- 2014Folding triblock copolymers
- 2014Folding polymers with pendant hydrogen bonding motifs in water : the effect of polymer length and concentration on the shape and size of single-chain polymeric nanoparticles
- 2014Folding polymers with pendant hydrogen bonding motifs in water : the effect of polymer length and concentration on the shape and size of single-chain polymeric nanoparticlescitations
- 2013Sticky Supramolecular Grafts Stretch Single Polymer Chainscitations
- 2013Orthogonal self-assembly in folding block copolymerscitations
- 2012Benzene-1,3,5-tricarboxamide : a versatile ordering moiety for supramolecular chemistry
- 2012Benzene-1,3,5-tricarboxamide : a versatile ordering moiety for supramolecular chemistrycitations
- 2010Hydrolases part I : enzyme mechanism, selectivity and control in the synthesis of well-defined polymerscitations
- 2007Supramolecular copolyesters with tunable properties
- 2007Supramolecular copolyesters with tunable propertiescitations
- 2007Poly(caprolactone-co-oxo-crown ether)-based poly(urethane)urea for soft tissue engineering applicationscitations
- 2006Oxo-crown-ethers as comonomers for tuning polyester properties
- 2006Oxo-crown-ethers as comonomers for tuning polyester propertiescitations
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article
Spectrally PAINTing a Single Chain Polymeric Nanoparticle at Super-Resolution
Abstract
Folding a polymer chain into a well-defined single-chain polymeric nanoparticle (SCPN) is a fascinating approach to obtaining structured and functional nanoparticles. Like all polymeric materials, SCPNs are heterogeneous in their nature due to the polydispersity of their synthesis: the stochastic synthesis of polymer backbone length and stochastic functionalization with hydrophobic and hydrophilic pendant groups make structural diversity inevitable. Therefore, in a single batch of SCPNs, nanoparticles with different physicochemical properties are present, posing a great challenge to their characterization at a single-particle level. The development of techniques that can elucidate differences between SCPNs at a single-particle level is imperative to capture their potential applications in different fields such as catalysis and drug delivery. Here, a Nile Red based spectral point accumulation for imaging in nanoscale topography (NR-sPAINT) super-resolution fluorescence technique was implemented for the study of SCPNs at a single-particle level. This innovative method allowed us to (i) map the small-molecule binding rates on individual SCPNs and (ii) map the polarity of individual SCPNs for the first time. The SCPN designs used here have the same polymeric backbone but differ in the number of hydrophobic groups. The experimental results show notable interparticle differences in the binding rates within the same polymer design. Moreover, a marked polarity shift between the different designs is observed. Interestingly, interparticle polarity heterogeneity was unveiled, as well as an intraparticle diversity, information which has thus far remained hidden by ensemble techniques. The results indicate that the addition of hydrophobic pendant groups is vital to determine binding properties and induces single-particle polarity diversity. Overall, NR-sPAINT represents a powerful approach to quantifying the single-particle polarity of SCPNs and paves the way to relate the structural heterogeneity to functionality at the ...