• Ray, Santanu
• Lamarre, Baptiste
• Bella, Angelo
• Ravi, Jascindra
• Ryadnov, Maxim G.
• Faruqui, Nilofar

Abstract

<p>An ability to construct biological matter from the molecule up holds promise for applications ranging from smart materials to integrated biophysical models for synthetic biology. Biomolecular self-assembly is an efficient strategy for biomaterial construction which can be programmed to support desired function. A challenge remains in replicating the strategy synthetically, that is at will, and differentially, that is for a specific function at a given length scale. Here we introduce a self-assembly topology enabling a net-like architectural mimetic of native extracellular matrices capable of differential responses to cell adhesion-enhanced mammalian cell attachment and proliferation, and enhanced resistance to bacterial colonization-at the native sub-millimeter length scales. The biological performance of such protein micro-nets directly correlates with their morphological and chemical properties, offering thus an application model for differential extracellular matrices.</p>

Topics

• impedance spectroscopy
• self-assembly