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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Lahann, Joerg
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (20/20 displayed)
- 2024Photo‐Arbuzov Reactions as a Broadly Applicable Surface Modification Strategycitations
- 2022Surfaces Decorated with Enantiomorphically Pure Polymer Nanohelices via Hierarchical Chirality Transfer across Multiple Length Scalescitations
- 2020Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapycitations
- 2020Molecular Changes in Vapor‐Based Polymer Thin Films Assessed by Characterization of Swelling Properties of Amine‐Functionalized Poly‐p-xylylene
- 2018Surface-initiated RAFT polymerization from vapor-based polymer coatingscitations
- 2018Water‐Stable Nanoporous Polymer Films with Excellent Proton Conductivitycitations
- 2017Polylutidinescitations
- 2017Polylutidines: Multifunctional Surfaces through Vapor-Based Polymerization of Substituted Pyridinophanescitations
- 2017pH-responsive aminomethyl functionalized poly(p-xylylene) coatings by chemical vapor deposition polymerizationcitations
- 2017Electrospun Polymer Fiber Lasers for Applications in Vapor Sensingcitations
- 2017Electrospun Polymer Fiber Lasers for Applications in Vapor Sensingcitations
- 2016Optical sensors from electrohydrodynamic jetted polymer fiber resonatorscitations
- 2016Optical sensors from electrohydrodynamic jetted polymer fiber resonatorscitations
- 2015Hierarchically Functionalized Magnetic Core/Multishell Particles and Their Postsynthetic Conversion to Polymer Capsulescitations
- 2015Free-Standing Nanomembranes Based on Selective CVD Deposition of Functional Poly- p -xylylenescitations
- 2014Fabrication of Highly Uniform Gel Coatings by the Conversion of Surface-Anchored Metal-Organic Frameworkscitations
- 2014Biofunctional Micropatterning of Thermoformed 3D Substratescitations
- 2014Interaction of Human Plasma Proteins with Thin Gelatin-Based Hydrogel Films: A QCM-D and ToF-SIMS Studycitations
- 2013Co-immobilization of Biomolecules on Ultrathin Reactive Chemical Vapor Deposition Coatings Using Multiple Click Chemistry Strategiescitations
- 2011Engineering, characterization and directional self-assembly of anisotropically modified nanocolloidscitations
Places of action
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article
Interaction of Human Plasma Proteins with Thin Gelatin-Based Hydrogel Films: A QCM-D and ToF-SIMS Study
Abstract
International audience ; In the fields of surgery and regenerative medicine, it is crucial to understand the interactions of proteins with the biomaterials used as implants. Protein adsorption directly influences cell-material interactions in vivo and, as a result, regulates, for example, cell adhesion on the surface of the implant. Therefore, the development of suitable analytical techniques together with well-defined model systems allowing for the detection, characterization, and quantification of protein adsorbates is essential. In this study, a protocol for the deposition of highly stable, thin gelatin-based films on various substrates has been developed. The hydrogel films were characterized morphologically and chemically. Due to the obtained low thickness of the hydrogel layer, this setup allowed for a quantitative study on the interaction of human proteins (albumin and fibrinogen) with the hydrogel by Quartz Crystal Microbalance with Dissipation Monitoring (QCM-D). This technique enables the determination of adsorbant mass and changes in the shear modulus of the hydrogel layer upon adsorption of human proteins. Furthermore, Secondary Ion Mass Spectrometry and principal component analysis was applied to monitor the changed composition of the topmost adsorbate layer. This approach opens interesting perspectives for a sensitive screening of viscoelastic biomaterials that could be used for regenerative medicine.