| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Pasic, Paul
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (1/1 displayed)
Places of action
| Organizations | Location | People |
|---|
article
Inhibition of Protein and Cell Attachment on Materials Generated from N‑(2-Hydroxypropyl) Acrylamide
Abstract
Effective control over biointerfacial interactions is essential for a broad range of biomedical applications. At this point in time, only a small range of polymers have been successfully used to reduce non-specific protein adsorption and subsequent cell attachment, including poly(ethylene glycol (PEG) based polymers, zwitterionic polymers andN-(2-hydroxypropyl) methacrylamide (HPMAm) based polymers. However, issues such as oxidative degradation and poor polymerization characteristics limit the applicability of most of these candidates. Here we have synthesized the monomer N-(2-hydroxypropyl)acrylamide (HPAm), examined its polymerization kinetics and evaluated its suitability for RAFT mediated polymerization in comparison to HPMAm.We also synthesized hydrogels using HPMAm and HPAm and evaluated the ability of HPAm polymers to reduce protein adsorption and cell attachment relative to those synthesised using HPMAm.Much faster polymerization kinetics were observed for HPAm relative to HPMAm and better control was achieved over the molecular weight distribution via RAFT mediated polymerization. The performance of hydrogels prepared from HPAm in the prevention of protein adsorption and cellular attachment was equal to that observed for materials made from HPMAm. These results open the door for HPAm based polymers in applications where effective control over biointerfacial interactions is required.