| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Patil, Avinash J.
University of Bristol
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2017Self-Assembly of Colloidal Nanocomposite Hydrogels Using 1D Cellulose Nanocrystals and 2D Exfoliated Organoclay Layerscitations
- 2016Chitin and carbon nanotube composites as biocompatible scaffolds for neuron growthcitations
- 2013Ionic liquids-based processing of electrically conducting chitin nanocomposite scaffolds for stem cell growthcitations
- 2013Directing Chondrogenesis of Stem Cells with Specific Blends of Cellulose and Silkcitations
- 2013The reinforcement effects of graphene oxide nanoplatelets on the mechanical and viscoelastic properties of natural rubber
- 2012Polymer/nucleotide droplets as bio-inspired functional micro-compartmentscitations
- 2011Guest-Molecule-Directed Assembly of Mesostructured Nanocomposite Polymer/Organoclay Hydrogelscitations
- 2011Supramolecular hydrogels derived from silver ion-mediated self-assembly of 5 '-guanosine monophosphatecitations
- 2009Membrane stabilization and transformation in organoclay-vesicle hybrid constructscitations
- 2009Immobilisation and encapsulation of functional protein-inorganic constructscitations
- 2007Bio-functional mesolamellar nanocomposites based on inorganic/polymer intercalation in purple membrane (bacteriorhodopsin) filmscitations
- 2007Influence of polymer co-intercalation on guest release from aminopropyl-functionalized magnesium phyllosilicate mesolamellar nanocompositescitations
Places of action
| Organizations | Location | People |
|---|
article
Directing Chondrogenesis of Stem Cells with Specific Blends of Cellulose and Silk
Abstract
Biomaterials that can stimulate stem cell differentiation without growth factor supplementation provide potent and cost-effective scaffolds for regenerative medicine. We hypothesize that a scaffold prepared from cellulose and silk blends can direct stem cell chondrogenic fate. We systematically prepared cellulose blends with silk at different compositions using an environmentally benign processing method based on ionic liquids as a common solvent.We tested the effect of blend compositions on the physical properties of the materials as well as on their ability to support mesenchymal stem cell (MSC) growth and chondrogenic differentiation. The stiffness and tensile strength of cellulose was significantly reduced by blending with silk.The characterized materials were tested using MSCs derived from four different patients. Growing MSCs on a specific blend combination of cellulose and silk in a 75:25 ratio significantly upregulated the chondrogenic marker genes SOX9, aggrecan and type II collagen in the absence of specific growth factors. This chondrogenic effect was neither found with neat cellulose nor the cellulose/silk 50:50 blend composition.No adipogenic or osteogenic differentiation is detected on the blends suggesting that the cellulose/silk 75:25 blend induces specific stem cell differentiation into the chondrogenic lineage without addition of the soluble growth factor TGF-β.The cellulose/silk blend we identified can be used both for in vitro tissue engineering and as an implantable device for stimulating endogenous stem cells to initiate cartilage repair.