| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Aparicio, Conrado
Universitat Internacional de Catalunya
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (42/42 displayed)
- 2022Relevant aspects of piranha passivation in Ti6Al4V alloy dental meshescitations
- 2021Hybrid Nanocoatings of Self-assembled Organic-Inorganic Amphiphiles for Prevention of Implant Infectionscitations
- 2021Utilizing a degradation prediction pathway system to understand how a novel methacrylate derivative polymer with flipped external ester groups retains physico-mechanical properties following esterase exposurecitations
- 2020A Novel Dental Polymer with a Flipped External Ester Group Design that Resists Degradation via Polymer Backbone Preservationcitations
- 2020Physical-chemical interactions between dental materials surface, salivary pellicle and Streptococcus gordoniicitations
- 2020Harnessing biomolecules for bioinspired dental biomaterialscitations
- 2020Polymeric nanoparticles protect the resin-dentin bonded interface from cariogenic biofilm degradationcitations
- 2019Present and future of tissue engineering scaffolds for dentin-pulp complex regenerationcitations
- 2019Nano-scale modification of titanium implant surfaces to enhance osseointegrationcitations
- 2018Effects of Molecular Weight and Concentration of Poly(Acrylic Acid) on Biomimetic Mineralization of Collagencitations
- 2018In vitro cell response on CP-Ti surfaces functionalized with TGF-β1 inhibitory peptidescitations
- 2017Interfacial degradation of adhesive composite restorations mediated by oral biofilms and mechanical challenge in an extracted tooth model of secondary cariescitations
- 2015Peptide-functionalized zirconia and new zirconia/titanium biocermets for dental applicationscitations
- 2015Biomimetic Mineralization of Recombinamer-Based Hydrogels toward Controlled Morphologies and High Mineral Densitycitations
- 2015Development of tantalum scaffold for orthopedic applications produced by space-holder methodcitations
- 2014Degradation in the dentin-composite interface subjected to multi-species biofilm challengescitations
- 2014Collagen-functionalised titanium surfaces for biological sealing of dental implantscitations
- 2014Assessing near infrared optical properties of ceramic orthodontic brackets using cross-polarization optical coherence tomographycitations
- 2013Bioactive Ceramic and Metallic Surfaces for Bone Engineeringcitations
- 2013Bioactive Ceramic and Metallic Surfaces for Bone Engineeringcitations
- 2012Imaging in vivo secondary caries and ex vivo dental biofilms using cross-polarization optical coherence tomographycitations
- 2012A reproducible oral microcosm biofilm model for testing dental materialscitations
- 2012Quantifying dental biofilm growth using cross-polarization optical coherence tomographycitations
- 2012Mineralization of peptide amphiphile nanofibers and its effect on the differentiation of human mesenchymal stem cellscitations
- 2012Biomimetic mineralization of woven bone-like nanocompositescitations
- 2011Effect of blasting treatment and Fn coating on MG63 adhesion and differentiation on titaniumcitations
- 2009Influence of the height of the external hexagon and surface treatment on fatigue life of commercially pure titanium dental implants
- 2008Oxidized NiTi surfaces enhance differentiation of osteoblast-like cellscitations
- 2007Low elastic modulus metals for joint prosthesiscitations
- 2007The influence of surface energy on competitive protein adsorption on oxidized NiTi surfacescitations
- 2007Electrochemical behaviour of oxidized NiTi shape memory alloys for biomedical applicationscitations
- 2006Bioceramics as nanomaterialscitations
- 2006Development of a biodegradable composite scaffold for bone tissue engineeringcitations
- 2006New oxidation treatment of NiTi shape memory alloys to obtain Ni-free surfaces and to improve biocompatibilitycitations
- 2005Static mechanical properties of hydroxyapatite (HA) powder-filled acrylic bone cementscitations
- 2005Surface characterization of completely degradable composite scaffoldscitations
- 2004Osseointegration of Grit-Blasted and Bioactive Titanium Implants
- 2002Effect of oxygen content on grain growth kinetics of titaniumcitations
- 2002Mechanical performance of acrylic bone cements containing different radiopacifying agentscitations
- 2002Growth of Bioactive Surfaces on Dental Implantscitations
- 2002Human-osteoblast proliferation and differentiation on grit-blasted and bioactive titanium for dental applicationscitations
- 2002Growth of bioactive surfaces on titanium and its alloys for orthopaedic and dental implantscitations
Places of action
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article
Biomimetic mineralization of woven bone-like nanocomposites
Abstract
<p>Ideal biomaterials for bone grafts must be biocompatible, osteoconductive, osteoinductive and have appropriate mechanical properties. For this, the development of synthetic bone substitutes mimicking natural bone is desirable, but this requires controllable mineralization of the collagen matrix. In this study, densified collagen films (up to 100 μm thick) were fabricated by a plastic compression technique and cross-linked using carbodiimide. Then, collagen-hydroxyapatite composites were prepared by using a polymer-induced liquid-precursor (PILP) mineralization process. Compared to traditional methods that produce only extrafibrillar hydroxyapatite (HA) clusters on the surface of collagen scaffolds, by using the PILP mineralization process, homogeneous intra- and extrafibrillar minerals were achieved on densified collagen films, leading to a similar nanostructure as bone, and a woven microstructure analogous to woven bone. The role of collagen cross-links on mineralization was examined and it was found that the cross-linked collagen films stimulated the mineralization reaction, which in turn enhanced the mechanical properties (hardness and modulus). The highest value of hardness and elastic modulus was 0.7 ± 0.1 and 9.1 ± 1.4 GPa in the dry state, respectively, which is comparable to that of woven bone. In the wet state, the values were much lower (177 ± 31 and 8 ± 3 MPa) due to inherent microporosity in the films, but still comparable to those of woven bone in the same conditions. Mineralization of collagen films with controllable mineral content and good mechanical properties provide a biomimetic route toward the development of bone substitutes for the next generation of biomaterials. This work also provides insight into understanding the role of collagen fibrils on mineralization.</p>