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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Bernard, Julien
Bureau de Recherches Géologiques et Minières
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (14/14 displayed)
- 2024Non-monotonic Impact of Statistical Copolymer Composition on the Kinetics of Capillary Rise Infiltrationcitations
- 2023AEM-derived watersheds in crystalline domain under volcanic cover
- 2022Ultrafast Remote Healing of Magneto-Responsive Thermoplastic Elastomer-Based Nanocompositescitations
- 2016A library of heptyl mannose-functionalized copolymers with distinct compositions, microstructures and neighboring non-sugar motifs as potent antiadhesives of type 1 piliated E. colicitations
- 2015Triethylene glycol-based poly(1,2,3-triazolium acrylate)s with enhanced ionic conductivitycitations
- 2015Highly Ordered Nanoporous Films from Supramolecular Diblock Copolymers with Hydrogen-Bonding Junctionscitations
- 20141,2,3-Triazolium-based poly(acrylate ionic liquid)scitations
- 2011Straightforward Preparation of Telechelic H-bonding Polymers From Difunctional Trithiocarbonates and Supramolecular Block Copolymers Thereofcitations
- 2010Bio-Sourced networks from thermal polyaddition of a starch-derived α-azide-ω-alkyne AB monomer with an A2B2 aliphatic cross-linker
- 2010Bio-Sourced Networks from Thermal Polyaddition of a Starch-Derived alpha-Azide-omega-Alkyne AB Monomer with an A(2)B(2) Aliphatic Cross-linker
- 2010Bio-Sourced polytriazoles from click chemistry step growth polymerization of diazide and dialkyne dianhydrohexitol stereoisomerscitations
- 2008Physical investigation of the impact of electrolessly deposited self-aligned caps on insulation of copper interconnectscitations
- 2007Shell-cross-linked micelles containing cationic polymers as gene delivery system synthesized via the RAFT process: Towards a more biocompatible gene delivery systemcitations
- 2007Shell-cross-linked micelles containing cationic polymers synthesized via the RAFT process: toward a more biocompatible gene delivery systemcitations
Places of action
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article
Shell-cross-linked micelles containing cationic polymers synthesized via the RAFT process: toward a more biocompatible gene delivery system
Abstract
Block copolymers poly(2-(dimethylamino) ethyl methacrylate)-b-poly(polyethylene glycol methacrylate) (PD-MAEMA-b-P(PEGMA)) were prepared via reversible addition fragmentation chain transfer polymerization (RAFT). The polymerization was found to proceed with the expected living behavior resulting in block copolymers with varying block sizes of low polydispersity (PDI < 1.3). The resulting block copolymer was self-assembled in an aqueous environment, leading to the formation of pH-responsive micelles. Further stabilization of the micellar system was performed in water using ethylene glycol dimethacrylate and the RAFT process to cross-link the shell. The cross-linked micelle was found to have properties significantly different from those of the uncross-linked block copolymer micelle. While a distinct critical micelle concentration (CMC) was observed using block copolymers, the CMC was absent in the cross-linked system. In addition, a better stability against disintegration was observed when altering the ionic strength such as the absence of changes of the hydrodynamic diameter with increasing NaCI concentration. Both cross-linked and uncross-linked micelles displayed good binding ability for genes. However, the cross-linked system exhibited a slightly superior tendency to bind oligonucleotides. Cytotoxicity tests confirmed a significant improvement of the biocompatibility of the synthesized cross-linked micelle compared to that of the highly toxic PDMAEMA. The cross-linked micelles were taken up by cells without causing any signs of cell damage, while the PDMAEMA homopolymer clearly led to cell death. © 2007 American Chemical Society.