| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Jenkins, Toby
University of Bath
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (8/8 displayed)
- 2018Development of an Infection-Responsive Fluorescent Sensor for the Early Detection of Urinary Catheter Blockagecitations
- 2016An in-situ infection detection sensor coating for urinary catheterscitations
- 2010Polymer-tethered bimolecular lipid membranescitations
- 2008Surface plasmon resonance-enhanced fluorescence implementation of a single-step competition assay: Demonstration of fatty acid measurement using an anti-fatty acid monoclonal antibody and a Cy5-labeled fatty acidcitations
- 2007Adhesion improvement of plasma-polymerized maleic anhydride films on gold using HMDSO/O-2 adhesion layerscitations
- 2007The effect of the ionophore valinomycin on biomimetic solid supported lipid DPPTE/EPC membranescitations
- 2002Chemical structure and properties of plasma-polymerized maleic anhydride filmscitations
- 2000Pulsed plasma deposited maleic anhydride thin films as supports for lipid bilayerscitations
Places of action
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article
Development of an Infection-Responsive Fluorescent Sensor for the Early Detection of Urinary Catheter Blockage
Abstract
Formation of crystalline biofilms following infection by Proteus mirabilis can lead to encrustation and blockage of longterm indwelling catheters, with serious clinical consequences. We describe a simple sensor, placed within the catheter drainage bag, to alert of impending blockage via a urinary color change. The pHresponsive sensor is a dual-layered polymeric “lozenge”, able to release the self-quenching dye 5(6)-carboxyfluorescein in response to the alkaline urine generated by the expression of bacterial urease. Sensor performance was evaluated within a laboratory model of the catheterized urinary tract, infected with both urease positive and negative bacterial strains under conditions of established infection, achieving an average “early warning” of catheter blockage of 14.5 h. Signaling only occurred following infection with urease positive bacteria. Translation of these sensors into a clinical environment would allow appropriate intervention before the occurrence of catheter blockage, a problem for which there is currently no effective control method.