| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Ferreira, Isabel
Universidade Nova de Lisboa
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (45/45 displayed)
- 2023Amorphous carbon thin filmscitations
- 2023A facile blow spinning technique for green cellulose acetate/polystyrene composite separator for flexible energy storage devicescitations
- 2022Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implantscitations
- 2020Conductive electrospun Polyaniline/Polyvinylpyrrolidone nanofibers: Electrical and morphological characterization of new yarns for electronic textilescitations
- 2020Conductive electrospun Polyaniline/Polyvinylpyrrolidone nanofibers: Electrical and morphological characterization of new yarns for electronic textilescitations
- 2019Synthesis of thermoelectric magnesium-silicide pastes for 3D printing, electrospinning and low-pressure spraycitations
- 2019Graphene oxide-reinforced aluminium-matrix nanostructured composites fabricated by accumulative roll bondingcitations
- 2017Improved thermoelectric properties of nanocrystalline hydrogenated silicon thin films by post-deposition thermal annealingcitations
- 2017New composite of natural hydraulic lime mortar with graphene oxidecitations
- 2017Optimization of Cuprous Oxides Thin Films to be used as Thermoelectric Touch Detectorscitations
- 2016Vanadium Pentoxide Alloyed with Graphite for Thin-Film Thermal Sensorscitations
- 2016Thermal and magnetic properties of chitosan-iron oxide nanoparticlescitations
- 2016Natural Nanofibres for Composite Applicationscitations
- 2016V2O5 Thin Films for Flexible and High Sensitivity Transparent Temperature Sensorcitations
- 2015Hydrogenated nanocrystalline silicon thin films with promising thermoelectric propertiescitations
- 2014Al-doped ZnO nanostructured powders by emulsion detonation synthesis - Improving materials for high quality sputtering targets manufacturingcitations
- 2014Broadband photocurrent enhancement in a-Si:H solar cells with plasmonic back reflectorscitations
- 2014Nanostructured p-type Cr/V2O5 thin films with boosted thermoelectric propertiescitations
- 2014Effects of surfactants on the magnetic properties of iron oxide colloidscitations
- 2013Ab initio calculations and measurements of thermoelectric properties of V2O5 filmscitations
- 2012Aluminum doped zinc oxide sputtering targets obtained from nanostructured powders: Processing and applicationcitations
- 2012Thermoelectric transport in V2O5 thin filmscitations
- 2011Improved glycemic control induced by both metformin and repaglinide is associated with a reduction in blood levels of 3-deoxyglucosone in nonobese patients with type 2 diabetescitations
- 2011Away from silicon era: the paper electronicscitations
- 2009Zinc oxide, a multifunctional material: from material to device applicationscitations
- 2008The effects of ZnO coating on the photoluminescence properties of porous silicon for the advanced optoelectronic devicescitations
- 2008Investigation of hydrocarbon coated porous silicon using PECVD technique to detect CO2 gas
- 2008Highly stable transparent and conducting gallium-doped zinc oxide thin films for photovoltaic applicationscitations
- 2007Effect of polymer strengtheners on the local environment of biocompatible glass as probed by fluorescencecitations
- 2006Electron transport and optical characteristics in amorphous indium zinc oxide filmscitations
- 2006The study of high temperature annealing of a-SiC:H films
- 2006Multifunctional Thin Film Zinc Oxide Semiconductors: Application to Electronic Devicescitations
- 2006Characterization of nanocrystalline silicon carbide filmscitations
- 2006Electrical properties of amorphous and nanocrystalline hydrogenated silicon films obtained by impedance spectroscopycitations
- 2006Performances of an in-line PECVD system used to produce amorphous and nanocrystalline silicon solar cellscitations
- 2005Role of buffer layer on the performances of amorphous silicon solar cells with incorporated nanoparticles produced by plasma enhanced chemical vapor deposition at 27.12 MHzcitations
- 2005Study of a-SiC : H buffer layer on nc-Si/a-Si : H solar cells deposited by PECVD technique.citations
- 2004Characterization of silicon carbide thin films prepared by VHF-PECVD technologycitations
- 2004Batch processing method to deposit a-Si
- 2002Metal-ferroelectric thin film devicescitations
- 2002Structural characterisation of NiTi thin film shape memory alloyscitations
- 2002Influence of hydrogen gas dilution on the properties of silicon-doped thin films prepared by the hot-wire plasma-assisted technique
- 2001Thin film metal oxide semiconductors deposited on polymeric substrates
- 2001Thin film position sensitive detectors based on pin amorphous silicon carbide structurescitations
- 2001Nanocrystalline p-type silicon films produced by hot wire plasma assisted techniquecitations
Places of action
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article
Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants
Abstract
This work was partially funded by the FEDER funds through the COMPETE 2020 Program and National Funds through the FCT – Portuguese Foundation for Science and Technology under the projects UIDB/50025/2020-2023 (CENIMAT/I3N), and also partially supported by the project ERC-CoG-2014. The authors would like to thank the use of the traction machine at the Biomaterials Laboratory from the Soft and Bio-functional Materials Group (CENIMAT/I3N). ; Implant-related infections, mainly caused by Staphylococcus aureus, are a major health concern. Treatment is challenging due to multi-resistant strains and the ability of S. aureus to adhere and form biofilms on bone and implant surfaces. The present work involved the preparation and evaluation of a novel dual polymeric film coating on stainless steel. Chitosan and polycaprolactone (PCL) multilayers, loaded with poly(methyl methacrylate) (PMMA) microspheres encapsulating vancomycin or daptomycin, produced by the dip-coating technique, allowed local antibiotic-controlled delivery for the treatment of implant-related infections. Enhanced adhesion of the film to the metal substrate surface was achieved by mechanical abrasion of its surface. Studies have shown that for both drugs the release occurs by diffusion, but the release profile depends on the type of drug (daptomycin or vancomycin), the pH of the solution, and whether the drug is freestanding (directly incorporated into the films) or encapsulated in PMMA microspheres. Daptomycin freestanding films reached 90% release after 1 day at pH 7.4 and 4 days at pH 5.5. In comparison, films with daptomycin encapsulated microspheres reached 90% release after 2 h at pH 5.5 and 2 days at pH 7.4. Vancomycin encapsulated and freestanding films showed a similar behavior reaching 90% release after 20 h of release at pH 5.5 and 2 and 3 days, respectively, at pH 7.4. Furthermore, daptomycin-loaded films showed activity (assessed by agar diffusion assays) against sensitive (ATCC 25923) and clinically isolated (MRSA) S. aureus strains. ...