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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Cain, M.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (11/11 displayed)
- 2024Ultrasound Stimulation of Piezoelectric Nanocomposite Hydrogels Boosts Chondrogenic Differentiation <i>in Vitro</i>, in Both a Normal and Inflammatory Milieu.citations
- 2016Dielectric constants of bulk ferroelectric PZTmeasured by terahertz time-domain spectroscopycitations
- 2013ZnO nanogenerators - Energy generation through scavenging vibration, advantages of using a diodecitations
- 2013ZnO nanostructured diodes - Enhancing energy generation through scavenging vibrationcitations
- 2013Measurement techniques for piezoelectric nanogeneratorscitations
- 2013Passivation of zinc oxide nanowires for improved piezoelectric energy harvesting devicescitations
- 2012Charge redistribution in piezoelectric energy harvesterscitations
- 2012Nanostructured p-n junctions for kinetic-to-electrical energy conversioncitations
- 2012Nanostructured zinc oxide piezoelectric energy generators based on semiconductor P-N junctionscitations
- 2010Pyroelectric contributions to piezoelectric hydrostatic Berlincourt methodcitations
- 2000Testing for statistical and market efficiency when forecast errors are non-normal: the NFL betting market revisted
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article
Ultrasound Stimulation of Piezoelectric Nanocomposite Hydrogels Boosts Chondrogenic Differentiation <i>in Vitro</i>, in Both a Normal and Inflammatory Milieu.
Abstract
The use of piezoelectric nanomaterials combined with ultrasound stimulation is emerging as a promising approach for wirelessly triggering the regeneration of different tissue types. However, it has never been explored for boosting chondrogenesis. Furthermore, the ultrasound stimulation parameters used are often not adequately controlled. In this study, we show that adipose-tissue-derived mesenchymal stromal cells embedded in a nanocomposite hydrogel containing piezoelectric barium titanate nanoparticles and graphene oxide nanoflakes and stimulated with ultrasound waves with precisely controlled parameters (1 MHz and 250 mW/cm<sup>2</sup>, for 5 min once every 2 days for 10 days) dramatically boost chondrogenic cell commitment <i>in vitro</i>. Moreover, fibrotic and catabolic factors are strongly down-modulated: proteomic analyses reveal that such stimulation influences biological processes involved in cytoskeleton and extracellular matrix organization, collagen fibril organization, and metabolic processes. The optimal stimulation regimen also has a considerable anti-inflammatory effect and keeps its ability to boost chondrogenesis <i>in vitro</i>, even in an inflammatory milieu. An analytical model to predict the voltage generated by piezoelectric nanoparticles invested by ultrasound waves is proposed, together with a computational tool that takes into consideration nanoparticle clustering within the cell vacuoles and predicts the electric field streamline distribution in the cell cytoplasm. The proposed nanocomposite hydrogel shows good injectability and adhesion to the cartilage tissue <i>ex vivo</i>, as well as excellent biocompatibility <i>in vivo,</i> according to ISO 10993. Future perspectives will involve preclinical testing of this paradigm for cartilage regeneration.