| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Gemmi, Mauro
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (29/29 displayed)
- 2024Ultrasound Stimulation of Piezoelectric Nanocomposite Hydrogels Boosts Chondrogenic Differentiation <i>in Vitro</i>, in Both a Normal and Inflammatory Milieu.citations
- 2023Chitosan decorated cobalt zinc ferrite nanoferrofluid composites for potential cancer hyperthermia therapy: anti-cancer activity, genotoxicity, and immunotoxicity evaluationcitations
- 2023Industrial Graphene Coating of Low-Voltage Copper Wires for Power Distributioncitations
- 2022Halide perovskites as disposable epitaxial templates for the phase-selective synthesis of lead sulfochloride nanocrystalscitations
- 2022Rapid self-healing in IR-responsive plasmonic indium tin oxide/polyketone nanocompositescitations
- 2022Supramolecular Isomerism in Cobalt(II) Coordination Polymers Built from 3,5-Bis(trifluoromethyl)benzoate and 4,4′-Bipyridinecitations
- 2022Competing phases in the room-temperature M 2 (2,6-ndc) 2 (dabco) metal-organic framework thin film synthesiscitations
- 2022Shedding light on the initial growth of ZnO during plasma-enhanced atomic layer deposition on vapor-deposited polymer thin filmscitations
- 2022Piezoelectric nanocomposite bioink and ultrasound stimulation modulate early skeletal myogenesiscitations
- 2022Piezoelectric nanocomposite bioink and ultrasound stimulation modulate early skeletal myogenesiscitations
- 2022Industrial graphene coating of low-voltage copper wires for power distributioncitations
- 2022Rapid Self-Healing in IR-Responsive Plasmonic Indium Tin Oxide/Polyketone Nanocompositescitations
- 2022Supramolecular Isomerism in Cobalt(II) Coordination Polymers Built from 3,5-Bis(trifluoromethyl)benzoate and 4,4'-Bipyridinecitations
- 2021Titania-decorated hybrid nano-architectures and their preliminary assessment in catalytic applications
- 2021Combined Approach of Mechanochemistry and Electron Crystallography for the Discovery of 1D and 2D Coordination Polymerscitations
- 2020Structural study of decrespignyite-(Y), a complex yttrium rare earth copper carbonate chloride, by three-dimensional electron and synchrotron powder diffraction
- 2020Nanocrystals of Lead Chalcohalides:A Series of Kinetically Trapped Metastable Nanostructurescitations
- 2020Nanocrystals of Lead Chalcohalidescitations
- 2020Cs 3 Cu 4 In 2 Cl 13 Nanocrystals:A Perovskite-Related Structure with Inorganic Clusters at A Sitescitations
- 2020Cs3Cu4In2Cl13 Nanocrystalscitations
- 20193D Electron Diffraction: The Nanocrystallography Revolutioncitations
- 2018Crystal Structures of Two Important Pharmaceuticals Solved by 3D Precession Electron Diffraction Tomographycitations
- 2018Ab initio structure determination of Cu2- xTe plasmonic nanocrystals by precession-assisted electron diffraction tomography and HAADF-STEM imagingcitations
- 2018Ab Initio Structure Determination of Cu2- xTe Plasmonic Nanocrystals by Precession-Assisted Electron Diffraction Tomography and HAADF-STEM Imagingcitations
- 2017Crystal Phases in Hybrid Metal-Semiconductor Nanowire Devicescitations
- 2014An advanced lithium-ion battery based on a graphene anode and a lithium iron phosphate cathodecitations
- 2011Synthesis, crystal structure and physico-chemical properties of the new quaternary oxide Sr5BiNi2O9.6citations
- 2011Quantitative texture analysis from powder-like electron diffraction datacitations
- 2010Fe3+ spin transition in CaFe2O4 at high pressurecitations
Places of action
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article
Ultrasound Stimulation of Piezoelectric Nanocomposite Hydrogels Boosts Chondrogenic Differentiation <i>in Vitro</i>, in Both a Normal and Inflammatory Milieu.
Abstract
The use of piezoelectric nanomaterials combined with ultrasound stimulation is emerging as a promising approach for wirelessly triggering the regeneration of different tissue types. However, it has never been explored for boosting chondrogenesis. Furthermore, the ultrasound stimulation parameters used are often not adequately controlled. In this study, we show that adipose-tissue-derived mesenchymal stromal cells embedded in a nanocomposite hydrogel containing piezoelectric barium titanate nanoparticles and graphene oxide nanoflakes and stimulated with ultrasound waves with precisely controlled parameters (1 MHz and 250 mW/cm<sup>2</sup>, for 5 min once every 2 days for 10 days) dramatically boost chondrogenic cell commitment <i>in vitro</i>. Moreover, fibrotic and catabolic factors are strongly down-modulated: proteomic analyses reveal that such stimulation influences biological processes involved in cytoskeleton and extracellular matrix organization, collagen fibril organization, and metabolic processes. The optimal stimulation regimen also has a considerable anti-inflammatory effect and keeps its ability to boost chondrogenesis <i>in vitro</i>, even in an inflammatory milieu. An analytical model to predict the voltage generated by piezoelectric nanoparticles invested by ultrasound waves is proposed, together with a computational tool that takes into consideration nanoparticle clustering within the cell vacuoles and predicts the electric field streamline distribution in the cell cytoplasm. The proposed nanocomposite hydrogel shows good injectability and adhesion to the cartilage tissue <i>ex vivo</i>, as well as excellent biocompatibility <i>in vivo,</i> according to ISO 10993. Future perspectives will involve preclinical testing of this paradigm for cartilage regeneration.