| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Yasir, Muhammad
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (18/18 displayed)
- 2024In situ polyaniline polymerization on electrospun cellulose acetate nanofibers derived from recycled waste filter butts of cigarettes for the enhanced removal of methyl orange and rhodaminecitations
- 2024Impact of cyclic thermal shocks on the electrochemical and tribological properties of Fe-based amorphous coatingcitations
- 2024Study of Graphene Oxide and Silver Nanowires Interactions and Its Association with Electromagnetic Shielding Effectivenesscitations
- 2024Shifting from sustained to delayed drug delivery systems: Encapsulated mesoporous silica-chitosan grafted polylactic acid-based composite approachcitations
- 2023Enhancement of antibacterial properties, surface morphology and In vitro bioactivity of hydroxyapatite-zinc oxide nanocomposite coating by electrophoretic deposition techniquecitations
- 2023Enhancement of Antibacterial Properties, Surface Morphology and In Vitro Bioactivity of Hydroxyapatite-Zinc Oxide Nanocomposite Coating by Electrophoretic Deposition Techniquecitations
- 2023Boosting photocatalytic degradation of estrone hormone by silica-supported g-C3N4/WO3 using response surface methodology coupled with Box-Behnken design
- 2023Photocatalytic degradation of atrazine and abamectin using <i>Chenopodium album</i> leaves extract mediated copper oxide nanoparticlescitations
- 2022Development and Characterization of Zein/Ag-Sr Doped Mesoporous Bioactive Glass Nanoparticles Coatings for Biomedical Applicationscitations
- 2022Melimine-modified 3D-printed polycaprolactone scaffolds for the prevention of biofilm-related biomaterial infectionscitations
- 2020Enhanced Tribological Properties of LA43M Magnesium Alloy by Ni60 Coating via Ultra-High-Speed Laser Claddingcitations
- 2020Mechanism of Action of Surface Immobilized Antimicrobial Peptides Against Pseudomonas aeruginosacitations
- 2019Quantifying the effects of basalt fibers on thermal degradation and fire performance of epoxy-based intumescent coating for fire protection of steel substratecitations
- 2019High-Performance Anticorrosive Polyester Coatings on Mild Steel in Mixed Acid Mixtures Environmentscitations
- 2017THE EFFECT OF CARBON NANOTUBES CONCENTRATION ON COMPLEX PERMITTIVITY OF NANOCOMPOSITEScitations
- 2015Oxidation of the GaAs semiconductor at the Al2O3/GaAs junctioncitations
- 2015Oxidation of the GaAs semiconductor at the Al2O3/GaAs junctioncitations
- 2014Wide band characterization of MWCNTs composites based on epoxy resincitations
Places of action
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article
Melimine-modified 3D-printed polycaprolactone scaffolds for the prevention of biofilm-related biomaterial infections
Abstract
Biomaterial-associated infections are one of the major causes of implant failure. These infections result from persistent bacteria that have adhered to the biomaterial surface before, during, or after surgery and have formed a biofilm on the implant's surface. It is estimated that 4 to 10% of implant surfaces are contaminated with bacteria; however, the infection rate can be as high as 30% in intensive care units in developed countries and as high as 45% in developing countries. To date, there is no clinical solution to prevent implant infection without relying on the use of high doses of antibiotics supplied systemically and/or removal of the infected device. In this study, melimine, a chimeric cationic peptide that has been tested in Phase I and II human clinical trials, was immobilized onto the surface of 3D-printed medical-grade polycaprolactone (mPCL) scaffolds via covalent binding and adsorption. X-ray photoelectron spectroscopy (XPS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS) spectra of melimine-treated surfaces confirmed immobilization of the peptide, as well as its homogeneous distribution throughout the scaffold surface. Amino acid analysis showed that melimine covalent and noncovalent immobilization resulted in a peptide density of ∼156 and ∼533 ng/cm, respectively. Furthermore, we demonstrated that the immobilization of melimine on mPCL scaffolds by 1-ethyl-3-[3-(dimethylamino)propyl] carbodiimide hydrochloride (EDC) coupling and noncovalent interactions resulted in a reduction ofcolonization by 78.7% and 76.0%, respectively, in comparison with the nonmodified control specimens. Particularly, the modified surfaces maintained their antibacterial properties for 3 days, which resulted in the inhibition of biofilm formation . This system offers a biomaterial strategy to effectively prevent biofilm-related infections on implant surfaces without relying on the use of prophylactic antibiotic treatment.