| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Prestat, Eric
Culham Centre for Fusion Energy
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (22/22 displayed)
- 2020Splenic Capture and In Vivo Intracellular Biodegradation of Biological-grade Graphene Oxide Sheetscitations
- 2019Enhanced Intraliposomal Metallic Nanoparticle Payload Capacity Using Microfluidic-Assisted Self-Assemblycitations
- 2018Study on the formation of thin film nanocomposite (TFN) membranes of polymers of intrinsic microporosity and graphene-like fillers: effect of lateral flake size and chemical functionalizationcitations
- 2018Study on the formation of thin film nanocomposite (TFN) membranes of polymers of intrinsic microporosity and graphene-like fillers: effect of lateral flake size and chemical functionalizationcitations
- 2017A Simple Electrochemical Route to Metallic Phase Trilayer MoS2: evaluation as Electrocatalysts and Supercapacitorscitations
- 2017A Simple Electrochemical Route to Metallic Phase Trilayer MoS2: evaluation as Electrocatalysts and Supercapacitorscitations
- 2017Enhanced organophilic separations with mixed matrix membranes of polymers of intrinsic microporosity and graphene-like fillerscitations
- 2017Role of 2D and 3D defects on the reduction of LaNiO 3 nanoparticles for catalysiscitations
- 2017In Situ Industrial Bimetallic Catalyst Characterisation using Scanning Transmission Electron Microscopy and X-Ray Absorption Spectroscopy at One Atmosphere and Elevated Temperaturecitations
- 2017In Situ Industrial Bimetallic Catalyst Characterisation using Scanning Transmission Electron Microscopy and X-Ray Absorption Spectroscopy at One Atmosphere and Elevated Temperaturecitations
- 2017Observing imperfection in atomic interfaces for van der Waals heterostructurescitations
- 2017EXPLORING NANOSCALE PRECURSOR REACTIONS IN ALLOY 600 IN H2/N2-H2O VAPOR USING IN SITU ANALYTICAL TRANSMISSION ELECTRON MICROSCOPYcitations
- 2017Mapping grain boundary heterogeneity at the nanoscale in a positive temperature coefficient of resistivity ceramiccitations
- 2017Mapping grain boundary heterogeneity at the nanoscale in a positive temperature coefficient of resistivity ceramiccitations
- 2017Mapping grain boundary heterogeneity at the nanoscale in a positive temperature coefficient of resistivity ceramiccitations
- 2017EXPLORING NANOSCALE PRECURSOR REACTIONS IN ALLOY 600 IN H 2 /N 2 -H 2 O VAPOR USING IN SITU ANALYTICAL TRANSMISSION ELECTRON MICROSCOPYcitations
- 2017Role of 2D and 3D defects on the reduction of LaNiO3 nanoparticles for catalysiscitations
- 2016The Application of In Situ Analytical Transmission Electron Microscopy to the Study of Preferential Intergranular Oxidation in Alloy 600citations
- 2016The Application of In Situ Analytical Transmission Electron Microscopy to the Study of Preferential Intergranular Oxidation in Alloy 600citations
- 2016Imaging the hydrated microbe-metal interface using nanoscale spectrum imagingcitations
- 2016Synthesis and characterization of composite membranes made of graphene and polymers of intrinsic microporositycitations
- 2014Real-time imaging and elemental mapping of AgAu nanoparticle transformationscitations
Places of action
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article
Splenic Capture and In Vivo Intracellular Biodegradation of Biological-grade Graphene Oxide Sheets
Abstract
Carbon nanomaterials, including 2D graphene-based materials (GBM) have shown promising applicability to drug delivery, tissue engineering, diagnostics and various other biomedical areas. However, to exploit the benefits of these materials in some of the areas mentioned, it is necessary to understand their possible toxicological implications and long-term fate in vivo. We previously demonstrated that following intravenous administration, 2D graphene oxide (GO) nanosheets are largely excreted via the kidneys, however, a small but significant portion of the material is sequestered in the spleen. Herein, we interrogate the potential consequences of this accumulation and the fate of the spleen-residing GO over a period of nine months. We show that our thoroughly characterized GO materials are not associated with any detectable pathological consequences in the spleen. Using confocal Raman mapping of tissue sections, we determine the sub-organ biodistribution of GO at various time points after administration. The cells largely responsible for taking up the material are confirmed using immunohistochemistry coupled with Raman spectroscopy, and transmission electron microscopy (TEM), respectively. This combination of techniques identified cells of the splenic marginal zone as the main site of GO bioaccumulation. In addition, through analyses using both bright-field TEM coupled with electron diffraction, and Raman spectroscopy, we reveal direct evidence of in vivo intracellular biodegradation of GO sheets with ultrastructural precision. This work offers critical information about biological processing and degradation of thin graphene oxide sheets by normal mammalian tissue, indicating that further development and exploitation of GO in biomedicine would be possible.