| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Castilho, Miguel
Eindhoven University of Technology
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (19/19 displayed)
- 2024Covalent Grafting of Functionalized MEW Fibers to Silk Fibroin Hydrogels to Obtain Reinforced Tissue Engineered Constructscitations
- 2024Covalent Grafting of Functionalized MEW Fibers to Silk Fibroin Hydrogels to Obtain Reinforced Tissue Engineered Constructscitations
- 20243D Printed Magneto-Active Microfiber Scaffolds for Remote Stimulation and Guided Organization of 3D In Vitro Skeletal Muscle Modelscitations
- 20233D printed magneto-active microfiber scaffolds for remote stimulation of 3D in vitro skeletal muscle modelscitations
- 20233D Printed Magneto‐Active Microfiber Scaffolds for Remote Stimulation and Guided Organization of 3D In Vitro Skeletal Muscle Modelscitations
- 20233D printed and punched porous surfaces of a non-resorbable, biphasic implant for the repair of osteochondral lesions improves repair tissue adherence and ingrowth
- 2023Multi-leveled Nanosilicate Implants Can Facilitate Near-Perfect Bone Healingcitations
- 2023Composite Graded Melt Electrowritten Scaffolds for Regeneration of the Periodontal Ligament-to-Bone Interfacecitations
- 2021Combinatorial fluorapatite-based scaffolds substituted with strontium, magnesium and silicon ions for mending bone defectscitations
- 2020Anisotropic hygro-expansion in hydrogel fibers owing to uniting 3D electrowriting and supramolecular polymer assemblycitations
- 2020Combining multi-scale 3D printing technologies to engineer reinforced hydrogel-ceramic interfacescitations
- 2020Combining multi-scale 3D printing technologies to engineer reinforced hydrogel-ceramic interfacescitations
- 2020Long-Term in Vivo Performance of Low-Temperature 3D-Printed Bioceramics in an Equine Modelcitations
- 2020Stable and Antibacterial Magnesium-Graphene Nanocomposite-Based Implants for Bone Repaircitations
- 2020Stable and Antibacterial Magnesium-Graphene Nanocomposite-Based Implants for Bone Repaircitations
- 2019Bi-layered micro-fibre reinforced hydrogels for articular cartilage regenerationcitations
- 2018Out-of-plane 3D-printed microfibers improve the shear properties of hydrogel compositescitations
- 2018Out-of-Plane 3D-Printed Microfibers Improve the Shear Properties of Hydrogel Compositescitations
- 2017Assessing bioink shape fidelity to aid material development in 3D bioprintingcitations
Places of action
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article
Long-Term in Vivo Performance of Low-Temperature 3D-Printed Bioceramics in an Equine Model
Abstract
Bone has great self-healing capacity, but above a certain critical size, bone defects will not heal spontaneously, requiring intervention to achieve full healing. Among the synthetic calcium phosphate (CaP) bone replacement materials, brushite (CaHPO4·2H2O)-based materials are of particular interest because of their degree of solubility and the related high potential to promote bone regeneration after dissolution. They can be produced tailor-made using modern three-dimensional (3D) printing technology. Although this type of implant has been widely tested in vitro, there are only limited in vivo data and less so in a relevant large animal model. In this study, material properties of a 3D-printed brushite-based scaffold are characterized, after which the material is tested by in vivo orthotopic implantation in the equine tuber coxae for 6 months. The implantation procedure was easy to perform and was well tolerated by the animals, which showed no detectable signs of discomfort. In vitro tests showed that compressive strength along the vertical axis of densely printed material was around 13 MPa, which was reduced to approximately 8 MPa in the cylindrical porous implant. In vivo, approximately 40% of the visible volume of the implants was degraded after 6 months and replaced by bone, showing the capacity to stimulate new bone formation. Histologically, ample bone ingrowth was observed. In contrast, empty defects were filled with fibrous tissue only, confirming the material’s osteoconductive capacity. It is concluded that this study provides proof that the 3D-printed brushite implants were able to promote new bone growth after 6 months’ implantation in a large animal model and that the new equine tuber coxae bone model that was used is a promising tool for bone regeneration studies.