| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Martin, Richard A.
Aston University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (40/40 displayed)
- 2024Multifunctional gallium doped bioactive glasses: a targeted delivery for antineoplastic agents and tissue repair against osteosarcomacitations
- 2020Evaluation of effectiveness of 45S5 bioglass doped with niobium for repairing critical-sized bone defect in in vitro and in vivo models
- 2020Evaluation of effectiveness of 45S5 bioglass doped with niobium for repairing critical-sized bone defect in in vitro and in vivo modelscitations
- 2020Photo-polymerisation variables influence the structure and subsequent thermal response of dental resin matricescitations
- 2019The antimicrobial efficacy of hypoxia mimicking cobalt oxide doped phosphate-based glasses against clinically relevant Gram positive, Gram negative bacteria and a fungal straincitations
- 2019The antimicrobial efficacy of hypoxia mimicking cobalt oxide doped phosphate-based glasses against clinically relevant Gram positive, Gram negative bacteria and a fungal strain
- 2019The Antimicrobial Efficacy of Hypoxia Mimicking Cobalt Oxide Doped Phosphate-Based Glasses against Clinically Relevant Gram Positive, Gram Negative Bacteria and a Fungal Straincitations
- 2018Comprehensive in vitro and in vivo studies of novel melt-derived Nb-substituted 45S5 bioglass reveal its enhanced bioactive properties for bone healingcitations
- 2017Atomic structure of chlorine containing calcium silicate glasses by neutron diffraction and 29Si solid-state NMR
- 2017Atomic structure of chlorine containing calcium silicate glasses by neutron diffraction and 29Si solid-state NMRcitations
- 2017Atomic structure of chlorine containing calcium silicate glasses by neutron diffraction and 29 Si solid-state NMRcitations
- 2017Atomic structure of Mg-based metallic glasses from molecular dynamics and neutron diffraction
- 2017Atomic structure of Mg-based metallic glasses from molecular dynamics and neutron diffractioncitations
- 2016Controlling particle size in the Stöber process and incorporation of calciumcitations
- 2016Bioactive sol-gel glasses at the atomic scale:the complementary use of advanced probe and computer modeling methods
- 2016Bioactive sol-gel glasses at the atomic scale : the complementary use of advanced probe and computer modeling methods
- 2016Probing crystallisation of a fluoro-apatite - mullite system using neutron diffractioncitations
- 2016Bioactive sol-gel glasses at the atomic scalecitations
- 2015Novel sol–gel preparation of (P2O5)0.4–(CaO)0.25–(Na2O)X–(TiO2)(0.35−X) bioresorbable glasses (X = 0.05, 0.1, and 0.15)citations
- 2014The effect of bioglass addition on mechanical and physical properties of photoactive UDMA-TEGDMA resin compositescitations
- 2013Effects of rare-earth co-doping on the local structure of rare-earth phosphate glasses using high and low energy X-ray diffractioncitations
- 2012Characterizing the hierarchical structures of bioactive sol-gel silicate glass and hybrid scaffolds for bone regenerationcitations
- 2012Effect of calcium source on structure and properties of sol-gel derived bioactive glassescitations
- 2012Structural characterization of titanium-doped Bioglass using isotopic substitution neutron diffractioncitations
- 2012Titanium phosphate glass microspheres for bone tissue engineering.citations
- 2011An X-ray micro-fluorescence study to investigate the distribution of Al, Si, P and Ca ions in the surrounding soft tissue after implantation of a calcium phosphate-mullite ceramic composite in a rabbit animal modelcitations
- 2010Structure of liquid and glassy ZnCl2citations
- 2009A study of the formation of amorphous calcium phosphate and hydroxyapatite on melt quenched Bioglass(A (R)) using surface sensitive shallow angle X-ray diffractioncitations
- 2009A molecular dynamics model of the atomic structure of dysprosium alumino-phosphate glasscitations
- 2009Bioactive glass sol-gel foam scaffoldscitations
- 2008Structure and thermal properties of yttrium alumino-phosphate glassescitations
- 2007The structure of the rare-earth phosphate glass (Sm2O3)0.205(P2O5)0.795 studied by anomalous dispersion neutron diffractioncitations
- 2006Direct observation of R...R distances in rare-earth (R) phosphate glasses by magnetic difference neutron diffractioncitations
- 2006Silica-clad neodymium-doped lanthanum phosphate fibers and fiber laserscitations
- 2006Direct observation of R.R distances in rare-earth (R) phosphate glasses by magnetic difference neutron diffractioncitations
- 2004Structure of rare-earth phosphate glasses by neutron diffractioncitations
- 2004Magnetic Differences on GEM - direct observation of closest R.R approach in rare-earth phosphate glasses
- 2003Identification of the relative distribution of rare-earth ions in phosphate glassescitations
- 2003Structure of lanthanum and cerium phosphate glasses by the method of isomorphic substitution in neutron diffractioncitations
- 2003Structure of dysprosium and holmium phosphate glasses by the method of isomorphic substitution in neutron diffractioncitations
Places of action
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article
The antimicrobial efficacy of hypoxia mimicking cobalt oxide doped phosphate-based glasses against clinically relevant Gram positive, Gram negative bacteria and a fungal strain
Abstract
<p>Bioactive phosphate glasses are of considerable interest for a range of soft and hard tissue engineering applications. The glasses are degradable and can release biologically important ions in a controlled manner. The glasses can also potentially be used as an antimicrobial delivery system. In the given study, novel cobalt-doped phosphate-based glasses, (P<sub>2</sub>O<sub>5</sub>)<sub>50</sub>(Na<sub>2</sub>O)<sub>20</sub>(CaO)<sub>30-x</sub>(CoO)<sub>x</sub> where 0 ≤ x (mol %) ≤ 10, were manufactured and characterized. As the cobalt oxide concentration increased, the rate of dissolution was observed to decrease. The antimicrobial potential of the glasses was studied using direct and indirect contact methods against both Escherichia coli (NCTC 10538) Staphylococcus aureus (ATCC 6538) and Candida albicans (ATCC 76615). The results showed strong, time dependent, and strain specific antimicrobial activity of the glasses against microorganisms when in direct contact. Antimicrobial activity (R) ≥ 2 was observed within 2 h against Escherichia coli, whereas a similar effect was achieved in 6 h against Staphylococcus aureus and Candida albicans. However, when in indirect contact, the dissolution products from the bioactive glasses failed to show an antimicrobial effect. Following direct exposure to the glasses for 7 days, osteoblast-like SAOS-2 cells showed a 5-fold increase in VEGF mRNA while THP-1 monocytic cells showed a 4-fold increase in VEGF mRNA expression when exposed to 10% CoO-doped glass compared with the cobalt free control glass. Endothelial cells stimulated with conditioned medium taken from cell cultures of THP-1 monocytes exposed to 10% CoO doped glass showed clear tubelike structure (blood vessel) formation after 4 h.</p>