| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Moroni, Lorenzo
Maastricht University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (43/43 displayed)
- 2024Well-Defined Synthetic Copolymers with Pendant Aldehydes Form Biocompatible Strain-Stiffening Hydrogels and Enable Competitive Ligand Displacementcitations
- 2023Thiol-ene conjugation of a VEGF peptide to electrospun scaffolds for potential applications in angiogenesiscitations
- 2023Chitin nanofibrils modulate mechanical response in tympanic membrane replacementscitations
- 2023Complementary Supramolecular Functionalization Enhances Antifouling Surfacescitations
- 2023Microstructured click hydrogels for cell contact guidance in 3Dcitations
- 2022Ancient fibrous biomaterials from silkworm protein fibroin and spider silk blends: Biomechanical patternscitations
- 2022Incorporation of Superparamagnetic Iron Oxide Nanoparticles into Collagen Formulation for 3D Electrospun Scaffoldscitations
- 20223D printing of jammed self-supporting microgels with alternative mechanism for shape fidelity, crosslinking and conductivitycitations
- 2022Additive Manufacturing of α-Amino Acid Based Poly(ester amide)s for Biomedical Applicationscitations
- 2022Universal Strategy for Designing ShapeMemory Hydrogelscitations
- 2022Tuning Hydrogels by Mixing Dynamic Cross-Linkers: Enabling Cell-Instructive Hydrogels and Advanced Bioinkscitations
- 2022HOW PRESERVATION PERIOD AFFECT THE BIOLOGICAL PROPERTIES OF ACELLULAR PLACENTAL SPONGE PATCHES?
- 2022Modular mixing of benzene-1,3,5-tricarboxamide supramolecular hydrogelators allows tunable biomimetic hydrogels for control of cell aggregation in 3Dcitations
- 20224D Printed Shape Morphing Biocompatible Materials Based on Anisotropic Ferromagnetic Nanoparticlescitations
- 2021Shaping and properties of thermoplastic scaffolds in tissue regeneration: The effect of thermal history on polymer crystallization, surface characteristics and cell fatecitations
- 2021Biomimetic Mechanically Strong One-Dimensional Hydroxyapatite/Poly(d,l-lactide) Composite Inducing Formation of Anisotropic Collagen Matrixcitations
- 2021Additive manufactured scaffolds for bone tissue engineering: Physical characterization of thermoplastic composites with functional fillerscitations
- 2021Bioprinting Via a Dual-Gel Bioink Based on Poly(Vinyl Alcohol) and Solubilized Extracellular Matrix towards Cartilage Engineeringcitations
- 2021Additive Manufactured Scaffolds for Bone Tissue Engineering: Physical Characterization of Thermoplastic Composites with Functional Fillerscitations
- 2021Controllable four axis extrusion-based additive manufacturing system for the fabrication of tubular scaffolds with tailorable mechanical propertiescitations
- 2021Chitin Nanofibril Application in Tympanic Membrane Scaffolds to Modulate Inflammatory and Immune Responsecitations
- 2021Biomimetic double network hydrogels: Combining dynamic and static crosslinks to enable biofabrication and control cell-matrix interactionscitations
- 20213D porous Ti6Al4V-beta-tricalcium phosphate scaffolds directly fabricated by additive manufacturingcitations
- 2021Long-term preservation effects on biological properties of acellular placental sponge patchescitations
- 2020Additive manufacturing of an elastic poly(ester)urethane for cartilage tissue engineeringcitations
- 20193D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineeringcitations
- 20193D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineeringcitations
- 2019Self-assembly of electrospun nanofibers into gradient honeycomb structurescitations
- 2018Influence of the nanofiber chemistry and orientation of biodegradable poly(butylene succinate)-based scaffolds on osteoblast differentiation for bone tissue regenerationcitations
- 2018Biofabrication strategies for 3D in vitro models and regenerative medicinecitations
- 2017Influence of Solution Properties and Process Parameters on the Formation and Morphology of YSZ and NiO Ceramic Nanofibers by Electrospinningcitations
- 2017Influence of Solution Properties and Process Parameters on the Formation and Morphology of YSZ and NiO Ceramic Nanofibers by Electrospinningcitations
- 2016Mimicking natural cell environments: design, fabrication and application of bio-chemical gradients on polymeric biomaterial substratescitations
- 2016Surface energy and stiffness discrete gradients in additive manufactured scaffolds for osteochondral regenerationcitations
- 2016Surface energy and stiffness discrete gradients in additive manufactured scaffolds for osteochondral regenerationcitations
- 2016Flexible Yttrium-Stabilized Zirconia Nanofibers Offer Bioactive Cues for Osteogenic Differentiation of Human Mesenchymal Stromal Cellscitations
- 2015Myoblast differentiation of human mesenchymal stem cells on graphene oxide and electrospun graphene oxide-polymer composite fibrous meshes: importance of graphene oxide conductivity and dielectric constant on their biocompatibilitycitations
- 2015Decellularized Extracellular Matrix Scaffolds for Cartilage Regenerationcitations
- 2015Distribution and Viability of Fetal and Adult Human Bone Marrow Stromal Cells in a Biaxial Rotating Vessel Bioreactor after Seeding on Polymeric 3D Additive Manufactured Scaffoldscitations
- 2014Interfacing polymeric scaffolds with primary pancreatic ductal adenocarcinoma cells to develop 3D cancer modelscitations
- 2014A biocomposite of collagen nanofibers and nanohydroxyapatite for bone regenerationcitations
- 2012Degradable amorphous scaffolds with enhanced mechanical properties and homogeneous cell distribution produced by a three‐dimensional fiber deposition methodcitations
- 2012Degradable amorphous scaffolds with enhanced mechanical properties and homogeneous cell distribution produced by a three-dimensional fiber deposition methodcitations
Places of action
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article
Additive Manufactured Scaffolds for Bone Tissue Engineering: Physical Characterization of Thermoplastic Composites with Functional Fillers
Abstract
Thermoplastic polymer-filler composites are excellent materials for bone tissue engineering (TE) scaffolds, combining the functionality of fillers with suitable load-bearing ability, biodegradability, and additive manufacturing (AM) compatibility of the polymer. Two key determinants of their utility are their rheological behavior in the molten state, determining AM processability and their mechanical load-bearing properties. We report here the characterization of both these physical properties for four bone TE relevant composite formulations with poly(ethylene oxide terephthalate)/poly(butylene terephthalate (PEOT/PBT) as a base polymer, which is often used to fabricate TE scaffolds. The fillers used were reduced graphene oxide (rGO), hydroxyapatite (HA), gentamicin intercalated in zirconium phosphate (ZrP-GTM) and ciprofloxacin intercalated in MgAl layered double hydroxide (MgAl-CFX). The rheological assessment showed that generally the viscous behavior dominated the elastic behavior (G" > G') for the studied composites, at empirically determined extrusion temperatures. Coupled rheological-thermal characterization of ZrP-GTM and HA composites showed that the fillers increased the solidification temperatures of the polymer melts during cooling. Both these findings have implications for the required extrusion temperatures and bonding between layers. Mechanical tests showed that the fillers generally not only made the polymer stiffer but more brittle in proportion to the filler fractions. Furthermore, the elastic moduli of scaffolds did not directly correlate with the corresponding bulk material properties, implying composite-specific AM processing effects on the mechanical properties. Finally, we show computational models to predict multimaterial scaffold elastic moduli using measured single material scaffold and bulk moduli. The reported characterizations are essential for assessing the AM processability and ultimately the suitability of the manufactured scaffolds for the envisioned bone regeneration application.