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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Mota, Carlos
European Commission
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (27/27 displayed)
- 2024Upcycling Fishing Net Waste and Metal Oxide from Electroplating Waste into Alga Cultivation Structures with Antibacterial Properties
- 2023Blast fragment impact of angle-ply composite structures for buildings wall protectioncitations
- 2023Chitin nanofibrils modulate mechanical response in tympanic membrane replacementscitations
- 2023Matrix metalloproteinase degradable, in situ photocrosslinked nanocomposite bioinks for bioprinting applicationscitations
- 2022Advanced Coatings of Polyureas for Building Blast Protection: Physical, Chemical, Thermal and Mechanical Characterizationcitations
- 2021Shaping and properties of thermoplastic scaffolds in tissue regeneration: The effect of thermal history on polymer crystallization, surface characteristics and cell fatecitations
- 2021Additive manufactured scaffolds for bone tissue engineering: Physical characterization of thermoplastic composites with functional fillerscitations
- 2021Bioprinting Via a Dual-Gel Bioink Based on Poly(Vinyl Alcohol) and Solubilized Extracellular Matrix towards Cartilage Engineeringcitations
- 2021Additive Manufactured Scaffolds for Bone Tissue Engineering: Physical Characterization of Thermoplastic Composites with Functional Fillerscitations
- 2021Controllable four axis extrusion-based additive manufacturing system for the fabrication of tubular scaffolds with tailorable mechanical propertiescitations
- 2021Chitin Nanofibril Application in Tympanic Membrane Scaffolds to Modulate Inflammatory and Immune Responsecitations
- 2021Study of the Filtration Performance of Multilayer and Multiscale Fibrous Structurescitations
- 2019Conception and characterization of different properties from a composite thermoformable with polymeric matrix and cellulosic fibres
- 2018Characterization of recycled carbon fibers reinforcing thermoplastic polymers
- 2018Influence of carbon nanotubes in the performance of a composite materials for ballistic helmets
- 2017Additive manufacturing of poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] scaffolds for engineered bone developmentcitations
- 2016Surface energy and stiffness discrete gradients in additive manufactured scaffolds for osteochondral regenerationcitations
- 2016Surface energy and stiffness discrete gradients in additive manufactured scaffolds for osteochondral regenerationcitations
- 2016Pseudo-ductile Braided Composite Rods (BCRs) produced by braidtrusion
- 2015Mechanical characterization of bio-epoxy ecocomposites reinforced with fibrous structures based on natural fibers
- 2015Processing and characterization of plates made from granulate of waste electrical cables
- 2015Mechanical properties of polypropylene/natural fiber composites: comparison with glass fiber
- 2014Estudo da adesão entre os materiais que constituem uma estrutura compósitas multicamada
- 2014Desenvolvimento e caracterização de varões compósitos híbridos para reforço de betão
- 2014Desenvolvimento de painéis compósitos multicamada com propriedades de resistência ao fogo
- 2014Development of multi-layer fibrous composites for fire resistant and sound insulating doors
- 2014Interfacing polymeric scaffolds with primary pancreatic ductal adenocarcinoma cells to develop 3D cancer modelscitations
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article
Additive Manufactured Scaffolds for Bone Tissue Engineering: Physical Characterization of Thermoplastic Composites with Functional Fillers
Abstract
Thermoplastic polymer-filler composites are excellent materials for bone tissue engineering (TE) scaffolds, combining the functionality of fillers with suitable load-bearing ability, biodegradability, and additive manufacturing (AM) compatibility of the polymer. Two key determinants of their utility are their rheological behavior in the molten state, determining AM processability and their mechanical load-bearing properties. We report here the characterization of both these physical properties for four bone TE relevant composite formulations with poly(ethylene oxide terephthalate)/poly(butylene terephthalate (PEOT/PBT) as a base polymer, which is often used to fabricate TE scaffolds. The fillers used were reduced graphene oxide (rGO), hydroxyapatite (HA), gentamicin intercalated in zirconium phosphate (ZrP-GTM) and ciprofloxacin intercalated in MgAl layered double hydroxide (MgAl-CFX). The rheological assessment showed that generally the viscous behavior dominated the elastic behavior (G" > G') for the studied composites, at empirically determined extrusion temperatures. Coupled rheological-thermal characterization of ZrP-GTM and HA composites showed that the fillers increased the solidification temperatures of the polymer melts during cooling. Both these findings have implications for the required extrusion temperatures and bonding between layers. Mechanical tests showed that the fillers generally not only made the polymer stiffer but more brittle in proportion to the filler fractions. Furthermore, the elastic moduli of scaffolds did not directly correlate with the corresponding bulk material properties, implying composite-specific AM processing effects on the mechanical properties. Finally, we show computational models to predict multimaterial scaffold elastic moduli using measured single material scaffold and bulk moduli. The reported characterizations are essential for assessing the AM processability and ultimately the suitability of the manufactured scaffolds for the envisioned bone regeneration application.