| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Michlewska, Sylwia
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (15/15 displayed)
- 2023Ruthenium metallodendrimer against triple-negative breast cancer in micecitations
- 2023Combination of Copper Metallodendrimers with Conventional Antitumor Drugs to Combat Cancer in In Vitro Modelscitations
- 2023Combination of Copper Metallodendrimers with Conventional Antitumor Drugs to Combat Cancer in In Vitro Models
- 2023Lipid-coated ruthenium dendrimer conjugated with doxorubicin in anti-cancer drug delivery: Introducing protocolscitations
- 2023Lipid-coated ruthenium dendrimer conjugated with doxorubicin in anti-cancer drug delivery: Introducing protocolscitations
- 2023Carbosilane ruthenium metallodendrimer as alternative anti-cancer drug carrier in triple negative breast cancer mouse model: A preliminary studycitations
- 2022Heterofunctionalized polyphenolic dendrimers decorated with caffeic acid: Synthesis, characterization and antioxidant activitycitations
- 2021Organometallic dendrimers based on Ruthenium(II) N-heterocyclic carbenes and their implication as delivery systems of anticancer small interfering RNAcitations
- 2020Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cellscitations
- 2020Copper (II) metallodendrimers combined with pro- apaoptotic siRNAs as a promising strategy against breast cancer cellscitations
- 2020Measurement methodology toward determination of structure-propertyrelationships in acrylic hydrogels with starch and nanogold designed forbiomedical applicationscitations
- 2019Combination of Ruthenium Dendrimers and Acoustically Propelled Gold Nanowires as a Platform for Active Intracellular Drug Delivery Towards Breast Cancer Therapycitations
- 2019Synthesis and Characterization of FITC Labelled Ruthenium Dendrimer as a Prospective Anticancer Drugcitations
- 2019Dendrimer for Templating the Growth of Porous Catechol-Coordinated Titanium Dioxide Frameworks: Toward Hemocompatible Nanomaterialscitations
- 2018Ruthenium dendrimers as carriers for anticancer siRNAcitations
Places of action
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article
Dendrimer for Templating the Growth of Porous Catechol-Coordinated Titanium Dioxide Frameworks: Toward Hemocompatible Nanomaterials
Abstract
Phosphorus dendrimers and nanosized metal oxide clusters are two dissimilar nanomaterials with promising applications in nanomedicine. Although outstanding holistic properties can be reached by the combination of organic and inorganic phases, few investigations were strikingly undertaken to associate these building blocks in a single nanostructured, open-framework hybrid material. With this aim, we designed herein five novel different generations of catechol-terminated phosphorus dendrimers (DGn: n = 1–5) and used them as structure-directing agents for titanium alkoxide mineralization. The covalent bonding occurring between peripheral catechols and soluble titanium oxo species and their further sol–gel cocondensation afford bimodal micromesoporous catechol-coordinated titanium dioxide nanomaterials. Their interplay with cells was assessed with a special emphasis on their hemolytic activity and cytotoxicity. Interestingly, enhanced biocompatibility was observed for these materials compared to their hybrid analogues built from ammonium- and phosphonate-terminated phosphorus dendrimers. These results demonstrate the importance of catechol-terminated groups both for bridging titanium dioxide clusters and for improving the materials’ compatibility. Overall, this study sheds light on the importance of tuning the surface-interface hybrid composition and provides a blueprint for the rational design of blood-compatible and drug-transporter materials.