| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Luxenhofer, Robert
University of Helsinki
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (23/23 displayed)
- 2025Amorphous solid dispersions of amphiphilic polymer excipients and indomethacin prepared by hot melt extrusioncitations
- 2024Amorphous solid dispersions of amphiphilic polymer excipients and indomethacin prepared by hot melt extrusioncitations
- 2024Perfusable Tissue Bioprinted into a 3D-Printed Tailored Bioreactor Systemcitations
- 2023Investigation of cationic ring-opening polymerization of 2-oxazolines in the "green" solvent dihydrolevoglucosenonecitations
- 2021Poly(2-ethyl-2-oxazoline-co-N-propylethylene imine)s by controlled partial reduction of poly(2-ethyl-2-oxazoline)citations
- 2021From Thermogelling Hydrogels toward Functional Bioinkscitations
- 2021Melt electrowriting of poly(vinylidene difluoride) using a heated collectorcitations
- 2021Probing the Complex Loading-Dependent Structural Changes in Ultrahigh Drug-Loaded Polymer Micelles by Small-Angle Neutron Scatteringcitations
- 2021Poly(2-ethyl-2-oxazoline-co-N-propylethylene imine)s by controlled partial reduction of poly(2-ethyl-2-oxazoline) : synthesis, characterization and cytotoxicitycitations
- 2021Inverse Thermogelation of Aqueous Triblock Copolymer Solutions into Macroporous Shear-Thinning 3D Printable Inkscitations
- 2021From Thermogelling Hydrogels toward Functional Bioinks : Controlled Modification and Cytocompatible Crosslinkingcitations
- 2021Poly(2-ethyl-2-oxazoline-co-N-propylethylene imine)s by controlled partial reduction of poly(2-ethyl-2-oxazoline): synthesis, characterization and cytotoxicitycitations
- 2021Think Beyond the Core : Impact of the Hydrophilic Corona on Drug Solubilization Using Polymer Micellescitations
- 2021Freeform direct laser writing of versatile topological 3D scaffolds enabled by intrinsic support hydrogelcitations
- 2021Poly(2-ethyl-2-oxazoline-co-N -propylethylene imine)s by controlled partial reduction of poly(2-ethyl-2-oxazoline): Synthesis, characterization and cytotoxicitycitations
- 2021Development of a 3D printable and highly stretchable ternary organic–inorganic nanocomposite hydrogelcitations
- 2020Think Beyond the Corecitations
- 2020Probing the Complex Loading-Dependent Structural Changes in Ultrahigh Drug-Loaded Polymer Micelles by Small-Angle Neutron Scatteringcitations
- 2020Probing the Complex Loading-Dependent Structural Changes in Ultrahigh Drug-Loaded Polymer Micelles by Small-Angle Neutron Scatteringcitations
- 2019Silanization of silica nanoparticles and their processing as nanostructured micro-raspberry powders - a route to control the mechanical properties of isoprene rubber compositescitations
- 2018Colloidal core-satellite supraparticles via preprogramed burst of nanostructured micro-raspberry particlescitations
- 2017Burstable nanostructured micro-raspberries: Towards redispersible nanoparticles from dry powderscitations
- 2011Structure-property relationship in cytotoxicity and cell uptake of poly(2-oxazoline) amphiphilescitations
Places of action
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article
Think Beyond the Core
Abstract
<p>Polymeric micelles are typically characterized as core-shell structures. The hydrophobic core is considered as a depot for hydrophobic molecules, and the corona-forming block acts as a stabilizing and solubilizing interface between the core and aqueous milieu. Tremendous efforts have been made to tune the hydrophobic block to increase the drug loading and stability of micelles, whereas the role of hydrophilic blocks is rarely investigated in this context, with poly(ethylene glycol) (PEG) being the gold standard of hydrophilic polymers. To better understand the role of the hydrophilic corona, a small library of structurally similar A-B-A-type amphiphiles based on poly(2-oxazoline)s and poly(2-oxazine)s is investigated by varying the hydrophilic block A utilizing poly(2-methyl-2-oxazoline) (pMeOx; A) or poly(2-ethyl-2-oxazoline) (pEtOx; A*). In terms of hydrophilicity, both polymers closely resemble PEG. The more hydrophobic block B bears either a poly(2-oxazoline) and poly(2-oxazine) backbone with C3 (propyl) and C4 (butyl) side chains. Surprisingly, major differences in loading capacities from A-B-A > A*-B-A > A*-B-A* is observed for the formulation with two poorly water-soluble compounds, curcumin and paclitaxel, highlighting the importance of the hydrophilic corona of polymer micelles used for drug formulation. The formulations are also characterized by various nuclear magnetic resonance spectroscopy methods, dynamic light scattering, cryogenic transmission electron microscopy, and (micro) differential scanning calorimetry. Our findings suggest that the interaction between the hydrophilic block and the guest molecule should be considered an important, but previously largely ignored, factor for the rational design of polymeric micelles.</p>