| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Gaffet, Eric
French National Centre for Scientific Research
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (14/14 displayed)
- 2019Doxorubicin-Loaded Thermoresponsive Superparamagnetic Nanocarriers for Controlled Drug Delivery and Magnetic Hyperthermia Applicationscitations
- 2019Doxorubicin Loaded Thermo-responsive Superparamagnetic Nanocarriers for Controlled Drug Delivery and Magnetic Hyperthermia Applicationscitations
- 2017One-step consolidation and precipitation hardening of an ultra-fine grained Al-Zn-Mg alloy by Spark Plasma Sinteringcitations
- 2017Efficient synthetic access to thermo-responsive core/shell nanoparticlescitations
- 2017Effect of heat treatments on the microstructure of an ultrafine-grained Al-Zn-Mg alloy produced by powder metallurgycitations
- 2015Procédé d'obtention d'un alliage cuivreux présentant un très haut niveau de caractéristiques mécaniques - Producing copper alloy used in aeronautics, comprises fragmenting initial alloy to obtain elemental fragments, mechanically synthesizing fragments by grinding the fragments in ball mill with high energy and flash sintering obtained powders - FR2985521B1
- 2013Control of FeAl Composition Produced by SPS Reactive Sintering from Mechanically Activated Powder Mixturecitations
- 2013Procédé d'obtention d'un alliage cuivreux présentant un très haut niveau de caractéristiques mécaniques - Producing copper alloy used in aeronautics, comprises fragmenting initial alloy to obtain elemental fragments, mechanically synthesizing fragments by grinding the fragments in ball mill with high energy and flash sintering obtained powders - FR2985521A1
- 2013Hallmarks of mechanochemistry: from nanoparticles to technologycitations
- 2012Procédé d'obtention d'un alliage cuivreux présentant un très haut niveau de caractéristiques mécaniques
- 2010On the mechanically induced crystallization of FCC phases by mechanical milling in ZrAlNiCu bulk metallic glassescitations
- 2007Main Recent Contributions to SHS from Francecitations
- 2006Combustion wave structure during the MoSi2 synthesis by Mechanically-Activated Self-propagating High-temperature Synthesis (MASHS) : In situ time-resolved investigations.citations
- 2006Structure and composition heterogeneity of a FeAl alloy prepared by one-step synthesis and consolidation processing and their influence on grain size characterization.citations
Places of action
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article
Doxorubicin Loaded Thermo-responsive Superparamagnetic Nanocarriers for Controlled Drug Delivery and Magnetic Hyperthermia Applications
Abstract
The present study reports on the development of thermo-responsive core/shell magnetic nanoparticles (MNPs) based on an iron oxide core and a thermo-responsive copolymer shell composed of 2-(2-methoxy) ethyl methacrylate (MEO2MA) and oligo (ethyleneglycol) methacrylate (OEGMA) moieties. Those smart nano-objects combine the magnetic properties of the core and the drug carrier properties of the polymeric shell. The loading of the anticancer drug doxorubicin (DOX) in the thermo-responsive MNPs via supramolecular interactions provides advanced features for the targeted delivery of DOX, which offers spatial and temporal control over the release of DOX. The iron oxide cores exhibit a superparamagnetic behavior with a saturation magnetization around 30 emu/g. The drug release experiments confirmed that only a small amount of DOX was released at room temperature, while almost 100% drug release was achieved after 52 h at 42°C for the Fe3O4@P(MEO2MA60OEGMA40) which exhibits an LCST of 41°C in culture media. Our data fit very well with the first order kinetic model. Moreover, the MNPs exhibit hyperthermia properties. Finally, the cytotoxicity towards human cancer SKOV-3 cells of the core/shell NPs was tested. The results showed that the polymer-capped NPs exhibited almost no toxicity at concentrations up to 12 µg.mL-1 while when loaded with DOX, a higher cytotoxicity and a decreased SKOV-3 cancer cell viability in a short time were observed. From the results obtained, it can be concluded that this smart superparamagnetic nanocarriers are promising for applications in multi-modal cancer therapy, with stealth properties and capable of delivering drug to the tumor.