| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Vuoriluoto, Maija
VTT Technical Research Centre of Finland
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (7/7 displayed)
- 2022Optical properties of an organic-inorganic hybrid film made of regenerated cellulose doped with light-scattering TiO2 particlescitations
- 2021Manufacture of all-wood sawdust-based particle board using ionic liquid-facilitated fusion processcitations
- 2017Engineering Nanocellulose Biointerfaces Toward Bioactivity and Strength
- 2017Engineering Nanocellulose Biointerfaces Toward Bioactivity and Strength ; Nanoselluloosabiorajapintojen ominaisuuksien muokkauscitations
- 2016Control of Protein Affinity of Bioactive Nanocellulose and Passivation Using Engineered Block and Random Copolymerscitations
- 2016Cellulose nanofibril film as a piezoelectric sensor materialcitations
- 2015Effect of molecular architecture of PDMAEMA-POEGMA random and block copolymers on their adsorption on regenerated and anionic nanocelluloses and evidence of interfacial water expulsioncitations
Places of action
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article
Control of Protein Affinity of Bioactive Nanocellulose and Passivation Using Engineered Block and Random Copolymers
Abstract
We passivated TEMPO-oxidized cellulose nanofibrils(TOCNF) toward human immunoglobulin G (hIgG) bymodification with block and random copolymers ofpoly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) andpoly(oligo(ethylene glycol) methyl ether methacrylate)(POEGMA). The block copolymers reversibly adsorbed onTOCNF and were highly effective in preventing nonspecificinteractions with hIgG, especially if short PDMAEMAblocks were used. In such cases, total protein rejectionwas achieved. This is in contrast to typical blockingagents, which performed poorly. When an anti-human IgGbiointerface was installed onto the passivated TOCNF,remarkably high affinity antibody-antigen interactionswere observed (0.90 ± 0.09 mg/m2). This is in contrast tothe nonpassivated biointerface, which resulted in asignificant false response. In addition, regeneration ofthe biointerface was possible by low pH aqueous wash.Protein A from Staphylococcus aureus was also utilized tosuccessfully increase the sensitivity for human IgGrecognition (1.28 ± 0.11 mg/m2). Overall, the developedsystem based on TOCNF modified with multifunctionalpolymers can be easily deployed as bioactive materialwith minimum fouling and excellent selectivity.