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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Chen, Xi
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (20/20 displayed)
- 2024Finite‐Element Analysis of an Antagonistic Bistable Shape Memory Alloy Beam Actuator
- 2024A Methodology for Robust Multislice Ptychographycitations
- 2024Strategic Fabrication of Au4Cu2 NC/ZIF-8 Composite Via In Situ Integration Technique for Enhanced Energy Storage Applicationscitations
- 2024On the importance of the cracking process description for dynamic crack initiation simulation
- 2024In situ synthesis of oriented Zn-Mn-Co-telluride on precursor free CuOcitations
- 2024Water‐Vapor Responsive Metallo‐Peptide Nanofiberscitations
- 2024Roadmap on optical communicationscitations
- 2023Cryogenic characteristics of graphene composites—evolution from thermal conductors to thermal insulatorscitations
- 20232D Si-Ge layered materials as anodes for alkali-cation (Na+, K+) batteriescitations
- 2023Experimental and theoretical insights of binder-free magnesium nickel cobalt selenide star-like nanostructure as electrodecitations
- 2023Structural study of atomically precise doped Au38-xAgx NCs@ ZIF-8 electrode material for energy storage applicationcitations
- 2023Understanding the Diffusion-Dominated Properties of MOF-Derived Ni–Co–Se/C on CuO Scaffold Electrode using Experimental and First Principle Studycitations
- 2023Grain size in low loss superconducting Ta thin films on c axis sapphirecitations
- 2023Bistable Actuation Based on Antagonistic Buckling SMA Beamscitations
- 2022Comparative study of ternary metal chalcogenides (MX; M= Zn–Co–Ni; X= S, Se, Te)citations
- 2022Factors affecting the growth formation of nanostructures and their impact on electrode materialscitations
- 2021Binder-free trimetallic phosphate nanosheets as an electrodecitations
- 2019Nonlinear electrical conductivity through the thickness of multidirectional carbon fiber compositescitations
- 2015Peptide-functionalized zirconia and new zirconia/titanium biocermets for dental applicationscitations
- 2015Biomimetic Mineralization of Recombinamer-Based Hydrogels toward Controlled Morphologies and High Mineral Densitycitations
Places of action
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article
Biomimetic Mineralization of Recombinamer-Based Hydrogels toward Controlled Morphologies and High Mineral Density
Abstract
<p>The use of insoluble organic matrices as a structural template for the bottom-up fabrication of organic-inorganic nanocomposites is a powerful way to build a variety of advanced materials with defined and controlled morphologies and superior mechanical properties. Calcium phosphate mineralization in polymeric hydrogels is receiving significant attention in terms of obtaining biomimetic hierarchical structures with unique mechanical properties and understanding the mechanisms of the biomineralization process. However, integration of organic matrices with hydroxyapatite nanocrystals, different in morphology and composition, has not been well-achieved yet at nanoscale. In this study, we synthesized thermoresponsive hydrogels, composed of elastin-like recombinamers (ELRs), to template mineralization of hydroxyapatite nanocrystals using a biomimetic polymer-induced liquid-precursor (PILP) mineralization process. Different from conventional mineralization where minerals were deposited on the surface of organic matrices, they were infiltrated into the frameworks of ELR matrices, preserving their microporous structure. After 14 days of mineralization, an average of 78 mineralization depth was achieved. Mineral density up to 1.9 g/cm<sup>3</sup> was found after 28 days of mineralization, which is comparable to natural bone and dentin. In the dry state, the elastic modulus and hardness of the mineralized hydrogels were 20.3 ± 1.7 and 0.93 ± 0.07 GPa, respectively. After hydration, they were reduced to 4.50 ± 0.55 and 0.10 ± 0.03 GPa, respectively. These values were lower but still on the same order of magnitude as those of natural hard tissues. The results indicated that inorganic-organic hybrid biomaterials with controlled morphologies can be achieved using organic templates of ELRs. Notably, the chemical and physical properties of ELRs can be tuned, which might help elucidate the mechanisms by which living organisms regulate the mineralization process.</p>