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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Mukherjee, R.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (6/6 displayed)
- 2022Engineering Antimicrobial Polymer Nanocomposites: <i>In Situ</i> Synthesis, Disruption of Polymicrobial Biofilms, and <i>In Vivo</i> Activity.citations
- 2016Multiscale simulations on the coarsening of Cu-rich precipitates in α-Fe using kinetic monte carlo, molecular dynamics, and phase-field simulationscitations
- 2015Experimental and Numerical Investigation on the Phase Separation Affected by Cooling Rates and Marangoni Convection in Cu-Cr Alloyscitations
- 2014Numerical study on solutal Marangoni instability in finite systems with a miscibility gapcitations
- 2012Effect of solutal Marangoni convection on motion, coarsening, and coalescence of droplets in a monotectic systemcitations
- 2012Multiscale simulations on the coarsening of Cu-rich precipitates in α-Fe using kinetic Monte Carlo, molecular dynamics and phase-field simulationscitations
Places of action
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article
Engineering Antimicrobial Polymer Nanocomposites: <i>In Situ</i> Synthesis, Disruption of Polymicrobial Biofilms, and <i>In Vivo</i> Activity.
Abstract
The increasing incidence of microbial infections and a limited arsenal of effective antibacterial and antifungal agents have entailed the need for new broad-spectrum therapeutics. Polymer-inorganic nanocomposites have emerged as an integral choice of antimicrobials but are limited by complicated synthesis, narrow-spectrum activity, and poor <i>in vivo</i> efficacy. Herein, chloride counterions of a nontoxic, moderately antibacterial polymer have been explored for <i>in situ</i> nanoprecipitation-based synthesis of water-soluble polymer-silver chloride nanocomposites. With the controlled release of silver ions, the nanocomposites were highly active against multidrug-resistant bacteria as well as fluconazole-resistant fungi. Alongside the elimination of metabolically inactive bacterial cells, the nanocomposites disrupted polymicrobial biofilms, unlike antibiotics and only silver-based ointments. This underlined the role of the engineered composite design, where the polymer interacted with the biofilm matrix, facilitating the penetration of nanoparticles to kill microbes. Further, the nanocomposite diminished <i>Pseudomonas aeruginosa</i> burden in mice skin infection (>99.9%) with no dermal toxicity proving its potential for clinical translation.