| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Tuck, Christopher
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (25/25 displayed)
- 2023Strategies for Integrating Metal Nanoparticles with Two-Photon Polymerization Process: Toward High Resolution Functional Additive Manufacturingcitations
- 2023Additively Manufactured 3D Micro-bioelectrodes for Enhanced Bioelectrocatalytic Operationcitations
- 2023Strategies for Integrating Metal Nanoparticles with Two-Photon Polymerization Processcitations
- 2022Reactive Jetting of High Viscosity Nanocomposites for Dielectric Elastomer Actuationcitations
- 2022Antimicrobial ‘inks’ for 3D printing: block copolymer-silver nanoparticle composites synthesised using supercritical CO2citations
- 2021The influence of printing parameters on multi-material two-photon polymerisation based micro additive manufacturingcitations
- 2021An imidazolium-based supramolecular gelator enhancing interlayer adhesion in 3D printed dual network hydrogelscitations
- 2021Bespoke 3D-Printed Polydrug Implants Created via Microstructural Control of Oligomerscitations
- 2021Bespoke 3D-Printed Polydrug Implants Created via Microstructural Control of Oligomerscitations
- 2018Compressive failure modes and energy absorption in additively manufactured double gyroid latticescitations
- 2018Selective recrystallization of cellulose composite powders and microstructure creation through 3D binder jettingcitations
- 2018Reactive material jetting of polyimide insulators for complex circuit board designcitations
- 2018Band gap behavior of optimal one-dimensional composite structures with an additive manufactured stiffenercitations
- 2018Author Correction: Additive manufacture of complex 3D Au-containing nanocomposites by simultaneous two-photon polymerisation and photoreduction
- 2018Scanning photocurrent microscopy of 3D printed light trapping structures in dye-sensitized solar cellscitations
- 20173D inkjet printing of electronics using UV conversioncitations
- 2017Additive manufacture of complex 3D Au-containing nanocomposites by simultaneous two-photon polymerisation and photoreductioncitations
- 2017Insights into the mechanical properties of several triplyperiodic minimal surface lattice structures made by polymeradditive manufacturingcitations
- 2016Quantification and characterisation of porosity in selectively laser melted Al–Si10–Mg using x-ray computed tomographycitations
- 2016Additive manufacture of three dimensional nanocomposite based objects through multiphoton fabricationcitations
- 2016Additive Manufacture of Three Dimensional Nanocomposite Based Objects through Multiphoton Fabricationcitations
- 20163D inkjet-printed UV-curable inks for multi-functional electromagnetic applicationscitations
- 2015Nano-hardness and microstructure of selective laser melted AlSi10Mg scan trackscitations
- 2014On the texture formation of selective laser melted Ti-6Al-4Vcitations
- 2014An experimental study into the effects of bulk and flow behaviour of laser sintering polymer powders on resulting part propertiescitations
Places of action
| Organizations | Location | People |
|---|
article
Bespoke 3D-Printed Polydrug Implants Created via Microstructural Control of Oligomers
Abstract
<p>Controlling the microstructure of materials by means of phase separation is a versatile tool for optimizing material properties. Phase separation has been exploited to fabricate intricate microstructures in many fields including cell biology, tissue engineering, optics, and electronics. The aim of this study was to use phase separation to tailor the spatial location of drugs and thereby generate release profiles of drug payload over periods ranging from 1 week to months by exploiting different mechanisms: polymer degradation, polymer diluent dissolution, and control of microstructure. To achieve this, we used drop-on-demand inkjet three-dimensional (3D) printing. We predicted the microstructure resulting from phase separation using high-throughput screening combined with a model based on the Flory-Huggins interaction parameter and were able to show that drug release from 3D-printed objects can be predicted from observations based on single drops of mixtures. We demonstrated for the first time that inkjet 3D printing yields controllable phase separation using picoliter droplets of blended photoreactive oligomers/monomers. This new understanding gives us hierarchical compositional control, from droplet to device, allowing release to be "dialled up"without manipulation of device geometry. We exemplify this approach by fabricating a biodegradable, long-term, multiactive drug delivery subdermal implant ("polyimplant") for combination therapy and personalized treatment of coronary heart disease. This is an important advance for implants that need to be delivered by cannula, where the shape is highly constrained and thus the usual geometrical freedoms associated with 3D printing cannot be easily exploited, which brings a hitherto unseen level of understanding to emergent material properties of 3D printing.</p>