| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Kumar, Ashok
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2023Strontium-Substituted Nanohydroxyapatite-Incorporated Poly(lactic acid) Composites for Orthopedic Applications: Bioactive, Machinable, and High-Strength Propertiescitations
- 2023Sb2Se3 Nanosheet Film-Based Devices for Ultraviolet Photodetection and Resistive Switchingcitations
- 2023Design consideration and recent developments in flexible, transparent and wearable antenna technology: A reviewcitations
- 2021Effect of Wheat Straw Ash on Fresh and Hardened Concrete Reinforced with Jute Fibercitations
- 2020Improved Bone Regeneration in Rabbit Bone Defects Using 3D Printed Composite Scaffolds Functionalized with Osteoinductive Factorscitations
- 2020Tin titanate – the hunt for a new ferroelectric perovskitecitations
- 2019Tin titanate – the hunt for a new ferroelectric perovskitecitations
- 2018Optically controlled polarization in highly oriented ferroelectric thin filmscitations
- 2017Optically controlled polarization in highly oriented ferroelectric thin filmscitations
- 2017Palladium-based ferroelectrics and multiferroics:theory and experimentcitations
- 2017Palladium-based ferroelectrics and multiferroics : theory and experimentcitations
- 2016Effect of thickness on dielectric, ferroelectric, and optical properties of Ni substituted Pb(Zr0.2Ti0.8)O3 thin filmscitations
- 2015Effect of thickness on dielectric, ferroelectric, and optical properties of Ni substituted Pb(Zr 0.2 Ti 0.8 )O 3 thin filmscitations
- 2014Dynamic nanocrystal response and high temperature growth of carbon nanotube-ferroelectric hybrid nanostructurecitations
- 2014Faceting oscillations in nano-ferroelectricscitations
- 2013Compositional engineering of BaTiO3/(Ba,Sr)TiO3 ferroelectric superlatticescitations
- 2012Magnon Raman spectroscopy and in-plane dielectric response in BiFeO3:Relation to the Polomska transitioncitations
- 2012Ferroelectric and Dielectric Properties of BaTiO3/Ba0.30Sr0.70TiO3 Superlatticescitations
- 2010Magnetic effects on dielectric and polarization behavior of multiferroic heterostructurescitations
- 2010Evaluation of boronate-containing polymer brushes and gels as substrates for carbohydrate-mediated adhesion and cultivation of animal cells.citations
- 2010Fabrication and characterization of the multiferroic birelaxor lead-iron-tungstate/lead-zirconate-titanatecitations
Places of action
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article
Improved Bone Regeneration in Rabbit Bone Defects Using 3D Printed Composite Scaffolds Functionalized with Osteoinductive Factors
Abstract
Large critical size bone defects are complicated to treat, and in many cases, autografts become a challenge due to size and availability. In such situations, a synthetic bone implant that can be patient-specifically designed and fabricated with control over parameters such as porosity, rigidity, and osteogenic cues can act as a potential synthetic bone substitute. In this study, we produced photocuring composite resins with poly(trimethylene carbonate) containing high ratios of bioactive ceramics and printed porous 3D composite scaffolds to be used as bone grafts. To enhance the overall surface area available for cell infiltration, the scaffolds were also filled with a macroporous cryogel. Furthermore, the scaffolds were functionalized with osteoactive factors: bone morphogenetic protein and zoledronic acid. The scaffolds were evaluated in vitro for biocompatibility and for functionality in vivo in critical bone defects (∼8 mm) in two clinically relevant rabbit models. These studies included a smaller study in rabbit tibia and a larger study in the rabbit cranium. It was observed that the bioactive molecule-functionalized 3D printed porous composite scaffolds provide an excellent conductive surface inducing higher bone formation and improved defect healing in both critical size long bones and cranial defects. Our findings provide strong evidence in favor of these composites as next generation synthetic bone substitutes.