693.932 PEOPLE
| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Seppälä, Jukka
Aalto University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (42/42 displayed)
- 2024Polypyrrole-modified flax fiber sponge impregnated with fatty acids as bio-based form-stable phase change materials for enhanced thermal energy storage and conversioncitations
- 2024Polypyrrole-modified flax fiber sponge impregnated with fatty acids as bio-based form-stable phase change materials for enhanced thermal energy storage and conversioncitations
- 2024A cradle-to-gate life cycle assessment of polyamide-starch biocomposites: carbon footprint as an indicator of sustainabilitycitations
- 2023Strontium-Substituted Nanohydroxyapatite-Incorporated Poly(lactic acid) Composites for Orthopedic Applications: Bioactive, Machinable, and High-Strength Propertiescitations
- 2023Flexible and conductive nanofiber textiles for leakage-free electro-thermal energy conversion and storagecitations
- 2023Heat-Induced Actuator Fibers: Starch-Containing Biopolyamide Composites for Functional Textilescitations
- 2023High-concentration lignin biocomposites with low-melting point biopolyamidecitations
- 2023Innovative integration of pyrolyzed biomass into polyamide 11: Sustainable advancements through in situ polymerization for enhanced mechanical, thermal, and additive manufacturing propertiescitations
- 2022Injectable thiol-ene hydrogel of galactoglucomannan and cellulose nanocrystals in delivery of therapeutic inorganic ions with embedded bioactive glass nanoparticlescitations
- 2022Injectable thiol-ene hydrogel of galactoglucomannan and cellulose nanocrystals in delivery of therapeutic inorganic ions with embedded bioactive glass nanoparticlescitations
- 2022Injectable thiol-ene hydrogel of galactoglucomannan and cellulose nanocrystals in delivery of therapeutic inorganic ions with embedded bioactive glass nanoparticlescitations
- 2022Conductive polyurethane/PEGylated graphene oxide composite for 3D-printed nerve guidance conduitscitations
- 2021Exfoliated clay nanocomposites of renewable long-chain aliphatic polyamide through in-situ polymerizationcitations
- 2021Exfoliated clay nanocomposites of renewable long-chain aliphatic polyamide through in-situ polymerizationcitations
- 2021Sustainable composites of surface-modified cellulose with low-melting point polyamidecitations
- 2021Novel long-chain aliphatic polyamide/surface-modified silicon dioxide nanocomposites: in-situ polymerization and propertiescitations
- 2021Novel long-chain aliphatic polyamide/surface-modified silicon dioxide nanocomposites: in-situ polymerization and propertiescitations
- 2021Selective Laser Sintering of Lignin-Based Compositescitations
- 2021Selective Laser Sintering of Lignin-Based Compositescitations
- 2021High-Performance and Biobased Polyamide/Functionalized Graphene Oxide Nanocomposites through In Situ Polymerization for Engineering Applicationscitations
- 2021High-Performance and Biobased Polyamide/Functionalized Graphene Oxide Nanocomposites through In Situ Polymerization for Engineering Applicationscitations
- 2020Improved Bone Regeneration in Rabbit Bone Defects Using 3D Printed Composite Scaffolds Functionalized with Osteoinductive Factorscitations
- 20203D scaffolding of fast photocurable polyurethane for soft tissue engineering by stereolithography: Influence of materials and geometry on growth of fibroblast cellscitations
- 20203D Scaffolding of fast photocurable polyurethane for soft tissue engineering by stereolithographycitations
- 2019Hydrolysis and drug release from poly(ethylene glycol)-modified lactone polymers with open porositycitations
- 2019Multiscale Structural Characterization of Biocompatible Poly(trimethylene carbonate) Photoreticulated Networkscitations
- 2019Mechanical properties of ultraviolet-assisted paste extrusion and postextrusion ultraviolet-curing of three-dimensional printed biocompositescitations
- 2018Low-temperature rheological and morphological characterization of SBS modified bitumencitations
- 2018An empirical constitutive model for complex glass-forming liquids using bitumen as a model materialcitations
- 2017Highly active platinum nanoparticles supported by nitrogen/sulfur functionalized graphene composite for ethanol electro-oxidationcitations
- 2016Development of nanocellulose scaffolds with tunable structures to support 3D cell culturecitations
- 2015Tailor-made hemicellulose-based hydrogels reinforced with nanofibrillated cellulosecitations
- 2015Interdiffusion and Spinodal Decomposition in Electrically Conducting Polymer Blendscitations
- 2015Composite films of nanofibrillated cellulose and O-acetyl galactoglucomannan (GGM) coated with succinic esters of GGM showing potential as barrier material in food packagingcitations
- 2015Fabrication of graphene-based 3D structures by stereolithographycitations
- 2014Nanofibrillated cellulose, poly(vinyl alcohol), montmorillonite clay hybrid nanocomposites with superior barrier and thermomechanical propertiescitations
- 2013An in vitro study of composites of poly(L-lactide-co-e-caprolactone), ß-tricalcium phosphate and ciprofloxacin intended for local treatment of osteomyelitiscitations
- 2012Processing and sustained in vitro release of rifampicin containing composites to enhance the treatment of osteomyelitiscitations
- 2011Chemical modification of fine paper base with amphiphilic copolymercitations
- 2006Poly(vinyl alcohol) and polyamide-66 nanocomposites prepared by electrospinningcitations
- 2006High-molar-mass polypropene with tunable elastic properties by hafnocene/borate catalystscitations
- 2002Effect of glycerol on behaviour of amylose and amylopectin filmscitations
Places of action
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article
Improved Bone Regeneration in Rabbit Bone Defects Using 3D Printed Composite Scaffolds Functionalized with Osteoinductive Factors
Abstract
Large critical size bone defects are complicated to treat, and in many cases, autografts become a challenge due to size and availability. In such situations, a synthetic bone implant that can be patient-specifically designed and fabricated with control over parameters such as porosity, rigidity, and osteogenic cues can act as a potential synthetic bone substitute. In this study, we produced photocuring composite resins with poly(trimethylene carbonate) containing high ratios of bioactive ceramics and printed porous 3D composite scaffolds to be used as bone grafts. To enhance the overall surface area available for cell infiltration, the scaffolds were also filled with a macroporous cryogel. Furthermore, the scaffolds were functionalized with osteoactive factors: bone morphogenetic protein and zoledronic acid. The scaffolds were evaluated in vitro for biocompatibility and for functionality in vivo in critical bone defects (∼8 mm) in two clinically relevant rabbit models. These studies included a smaller study in rabbit tibia and a larger study in the rabbit cranium. It was observed that the bioactive molecule-functionalized 3D printed porous composite scaffolds provide an excellent conductive surface inducing higher bone formation and improved defect healing in both critical size long bones and cranial defects. Our findings provide strong evidence in favor of these composites as next generation synthetic bone substitutes.