| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Latini, Alessandro
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (9/9 displayed)
- 2023A simple synthetic approach to BaZrS3, BaHfS3, and their solid solutionscitations
- 2023A simple synthetic approach to BaZrS<sub>3</sub>, BaHfS<sub>3</sub>, and their solid solutionscitations
- 2020Novel Hybrid Composites Based on PVA/SeTiO2 Nanoparticles and Natural Hydroxyapatite for Orthopedic Applications: Correlations between Structural, Morphological and Biocompatibility Propertiescitations
- 2020Ion Migration‐Induced Amorphization and Phase Segregation as a Degradation Mechanism in Planar Perovskite Solar Cells
- 2019Engineering Human-Scale Artificial Bone Grafts for Treating Critical-Size Bone Defectscitations
- 2016Catalytic Chemical Vapour Deposition on MFe 2 O 4 –SiO 2 (M = Co, Mn, Ni) Nanocomposite Aerogel Catalysts for the Production of Multi Walled Carbon Nanotubescitations
- 2015Solid Solutions of Rare Earth Cations in Mesoporous Anatase Beads and Their Performances in Dye-Sensitized Solar Cellscitations
- 2013Poly(ethylenglycol)dimethylether-lithium bis(trifluoromethanesulfonyl)imide, PEG500DME-LiTFSI, as high viscosity electrolyte for lithium ion batteriescitations
- 2012Nickel-Layer Protected, Carbon-Coated Sulfur Electrode for Lithium Batterycitations
Places of action
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article
Engineering Human-Scale Artificial Bone Grafts for Treating Critical-Size Bone Defects
Abstract
The manufacturing of artificial bone grafts can potentially circumvent the issues associated with current bone grafting treatments for critical-size bone defects caused by pathological disorders, trauma, or massive tumor ablation. In this study, we report on a potentially patient-specific fabrication process in which replicas of bone defects, in particular zygomatic and mandibular bones and phalanxes of a hand finger, were manufactured by laser stereolithography and used as templates for the creation of PDMS molds. Gas-inwater foams were cast in the molds, rapidly frozen, freezedried, and cross-linked. Since bone matrix consists essentially of collagen and hydroxyapatite, biomimetic scaffolds were fabricated using gelatin and hydroxyapatite in a ratio very similar to that found in bone. The obtained composite scaffolds were excellent replicas of the original bone defects models and presented both a superficial and internal porous texture adequate for cellular and blood vessels infiltration. In particular, scaffolds exhibited a porous texture consisting of pores and interconnects with average size of about 300 and 100 μm, respectively, and a porosity of 90%. In vitro culture tests using hMSCs demonstrated scaffold biocompatibility and capacity in inducing differentiation toward osteoblasts progenitors. In vivo cellularized implants showed bone matrix deposition and recruitment of blood vessels. Overall, the technique/materials combination used in this work led to the fabrication of promising mechanically stable, bioactive, and biocompatible composite scaffolds with well-defined architectures potentially valuable in the regeneration of patient-specific bone defects.