| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Dolatshahi-Pirouz, Alireza
Technical University of Denmark
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (19/19 displayed)
- 2024Engineering Photo-Cross-Linkable MXene-Based Hydrogels:Durable Conductive Biomaterials for Electroactive Tissues and Interfacescitations
- 2024Engineering Photo-Cross-Linkable MXene-Based Hydrogels: Durable Conductive Biomaterials for Electroactive Tissues and Interfacescitations
- 2023Multi-leveled Nanosilicate Implants Can Facilitate Near-Perfect Bone Healingcitations
- 2023Composite Graded Melt Electrowritten Scaffolds for Regeneration of the Periodontal Ligament-to-Bone Interfacecitations
- 2022Bioinspired gelatin/bioceramic composites loaded with bone morphogenetic protein-2 (BMP-2) promote osteoporotic bone repaircitations
- 2021Design and construction of a novel measurement device for mechanical characterization of hydrogelscitations
- 2021Design and construction of a novel measurement device for mechanical characterization of hydrogels:A case studycitations
- 2021Combinatorial fluorapatite-based scaffolds substituted with strontium, magnesium and silicon ions for mending bone defectscitations
- 2021Rheological characterization of 3D printable geopolymerscitations
- 20193D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineeringcitations
- 20193D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineeringcitations
- 2019Self-Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?citations
- 2019Silica nanoparticle surface chemistry: An important trait affecting cellular biocompatibility in two and three dimensional culture systemscitations
- 2019Combating Microbial Contamination with Robust Polymeric Nanofibers: Elemental Effect on the Mussel-Inspired Cross-Linking of Electrospun Gelatincitations
- 2017Nanoreinforced Hydrogels for Tissue Engineering: Biomaterials that are Compatible with Load-Bearing and Electroactive Tissuescitations
- 2017Nanoreinforced hydrogels for tissue engineering:Biomaterials that are compatible with load-bearing and electroactive tissuescitations
- 2016Injectable shear-thinning nanoengineered hydrogels for stem cell deliverycitations
- 2011Growth characteristics of inclined columns produced by Glancing Angle Deposition (GLAD) and colloidal lithographycitations
- 2010Synthesis of functional nanomaterials via colloidal mask templating and glancing angle deposition (GLAD)”
Places of action
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article
Combating Microbial Contamination with Robust Polymeric Nanofibers: Elemental Effect on the Mussel-Inspired Cross-Linking of Electrospun Gelatin
Abstract
Designing biocompatible nanofibrous mats capable of preventing microbial colonization from resident and nosocomial bacteria for an extended period remains an unmet clinical need. In the present work, we designed antibiotic free durable antimicrobial nanofiber mats by taking advantage of synergistic interactions between polydopamine(pDA) and metal ions with varying degree of antimicrobial properties (Ag<sup>+</sup>, Mg<sup>2+</sup>, Ca<sup>2+</sup>, and Zn<sup>2+</sup>). Microscopic analysis showed successful pDA-mediated cross-linking of the gelatin nanofibers, which further improved by the inclusion of Ag<sup>+</sup>, Mg<sup>2+</sup>, and Ca<sup>2+</sup> ions as supported by mechanical and thermal studies. Spectroscopic results reinforce the presence of strong interactions between pDA and metal ions in the composite nanofibers, leading to generation of robust polymeric nanofibers. We further showed that strong pDA–Ag interactions attenuated the cell cytotoxicity and anticell proliferative properties of silver ions for immortalized keratinocytes and primary human dermal fibroblasts. pDA–Ca<sup>2+</sup>/Zn<sup>2+</sup> interactions rendered the composite structure sterile against methicillin-resistant <i>Staphylococcus aureus</i> and vancomycin-resistant <i>Enterococcus faecium</i> strains, whereas the silver ion-incorporated composite mats displayed broad spectrum antibacterial activity against both Gram-positive/-negative bacteria and yeast strains. We showed that the strong pDA–Ag interactions help retaining long-term antimicrobial activity of the mats for at least 40 days while attenuating mammalian cell cytotoxicity of silver ions for skin cells. Overall, the results suggest the potential of pDA–metal ion interactions for engineering sterile nanofibrous mats and expanding the antibiotic armamentarium against drug-resistant pathogens.