| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Khimyak, Yaroslav Z.
University of East Anglia
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (13/13 displayed)
- 2024Surface modification of cellulose nanomaterials with amine functionalized fluorinated ionic liquids for hydrophobicity and high thermal stabilitycitations
- 2024Self-healing composite coating fabricated with a cystamine crosslinked cellulose nanocrystal stabilized Pickering emulsioncitations
- 2022Amphiphilic Cellulose Nanocrystals for Aqueous Processing of Thermoplastics:ACS Applied Polymer Materialscitations
- 2022Amphiphilic cellulose nanocrystals for aqueous processing of thermoplasticscitations
- 2019Thermosensitive supramolecular and colloidal hydrogels via self-assembly modulated by hydrophobized cellulose nanocrystalscitations
- 2018Nanocrystallization of rare tolbutamide form V in mesoporous MCM-41 silicacitations
- 201619F NMR spectroscopy as a highly sensitive method for the direct monitoring of confined crystallization within nanoporous materialscitations
- 2016Structure and mobility of lactose in lactose/sodium montmorillonite nanocompositescitations
- 2016Structural properties, order-disorder phenomena and phase stability of orotic acid crystal formscitations
- 2010Chemical bonding assembly of multifunctional oxide nanocompositescitations
- 2009Reversible methane storage in a polymer-supported semi-clathrate hydrate at ambient temperature and pressurecitations
- 2008Bulk superconductivity at 38 K in a molecular systemcitations
- 2006Methylaminated potassium fulleride, (CH3NH2)K 3C60: Towards hyperexpanded fulleride latticescitations
Places of action
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article
Nanocrystallization of rare tolbutamide form V in mesoporous MCM-41 silica
Abstract
Encapsulation of pharmaceuticals inside nanoporous materials is of increasing interest due to their possible applications as new generation therapeutics, theranostic platforms, or smart devices. Mesoporous silicas are leading materials to be used as nanohosts for pharmaceuticals. Further development of new generation of nanoscale therapeutics requires complete understanding of the complex host−guest interactions of organic molecules confined in nanosized chambers at different length scales. In this context, we present results showing control over formation and phase transition of nanosize crystals of model flexible pharmaceutical molecule tolbutamide confined inside 3.2 nm pores of the MCM-41 host. Using low loading levels (up to 30 wt %), we were able to stabilize the drug in highly dynamic amorphous/disordered state or direct the crystallization of the drug into highly metastable nanocrystalline form V of tolbutamide (at loading levels of 40 and 50 wt %), providing first experimental evidence for crystallization of pharmaceuticals inside the pores as narrow as 3.2 nm.