Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (1/1 displayed)

  • 2016In Vivo Precipitation of Poorly Soluble Drugs from Lipid-Based Drug Delivery Systems31citations

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Chart of shared publication
Broek, E. Van Den
1 / 1 shared
Rades, Thomas
1 / 107 shared
Wasan, K. M.
1 / 1 shared
Mu, Huiling
1 / 2 shared
Sassene, P. J.
1 / 2 shared
Mosgaard, M. D.
1 / 1 shared
Klitgaard, Mette
1 / 1 shared
Müllertz, Anette
1 / 18 shared
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2016

Co-Authors (by relevance)

  • Broek, E. Van Den
  • Rades, Thomas
  • Wasan, K. M.
  • Mu, Huiling
  • Sassene, P. J.
  • Mosgaard, M. D.
  • Klitgaard, Mette
  • Müllertz, Anette
OrganizationsLocationPeople

article

In Vivo Precipitation of Poorly Soluble Drugs from Lipid-Based Drug Delivery Systems

  • Broek, E. Van Den
  • Rades, Thomas
  • Wasan, K. M.
  • Mu, Huiling
  • Sassene, P. J.
  • Michaelsen, M. H.
  • Mosgaard, M. D.
  • Klitgaard, Mette
  • Müllertz, Anette
Abstract

<p>Precipitation of poorly water-soluble drugs from lipid-based drug delivery systems (LbDDS) has been studied extensively during in vitro lipolysis but has never been shown in vivo. The aim of this study was therefore to investigate if drug precipitation can occur from LbDDS during transit of the gastrointestinal tract in vivo. Rats were administered 300 μL of either of two LbDDS (LbDDS I and LbDDS II) loaded with danazol or fenofibrate (or paracetamol to assess gastric emptying). The rats were euthanized at various time points after administration of both LbDDS containing either drug, and the contents of the stomach and proximal part of the small intestine were harvested. The contents were analyzed for crystalline drug by X-ray powder diffraction and polarized light microscopy. No drug precipitation was evident in the stomach or the intestine after administration of LbDDS I containing danazol at the tested time points. Fenofibrate precipitation was absent in the stomach initially after administration of LbDDS I, but was evident in the stomach 90 min after dosing. No crystalline fenofibrate was observed in the intestine. Danazol and fenofibrate precipitation was evident in the stomach following administration of LbDDS II containing either drug, but not in the intestine at the tested time point. Drug precipitation from LbDDS was observed in the stomach, but not in the intestine, which is contrary to what in vitro lipolysis data (obtained under human GI conditions) suggests. Thus, precipitation of drugs from LbDDS in vivo in rats is much lower than might be anticipated from in vitro lipolysis data.</p>

Topics
  • impedance spectroscopy
  • precipitation
  • Polarized light microscopy