| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Kostarelos, Kostas
University of Manchester
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (24/24 displayed)
- 2022Hazard Assessment of Abraded Thermoplastic Composites Reinforced with Reduced Graphene Oxidecitations
- 2021Viscoelastic surface electrode arrays to interface with viscoelastic tissuescitations
- 2020Production and processing of graphene and related materials
- 2020Production and processing of graphene and related materialscitations
- 2020Production and processing of graphene and related materialscitations
- 2020Production and processing of graphene and related materialscitations
- 2020Production and processing of graphene and related materialscitations
- 2020Production and processing of graphene and related materialscitations
- 2020Production and processing of graphene and related materialscitations
- 2020Production and processing of graphene and related materialscitations
- 2020Production and processing of graphene and related materials
- 2020Production and processing of graphene and related materialscitations
- 2020Splenic Capture and In Vivo Intracellular Biodegradation of Biological-grade Graphene Oxide Sheetscitations
- 2019Enhanced Intraliposomal Metallic Nanoparticle Payload Capacity Using Microfluidic-Assisted Self-Assemblycitations
- 2018Immunological impact of graphene oxide sheets in the abdominal cavity is governed by surface reactivitycitations
- 2015Nanocomposite hydrogels: 3D polymer-nanoparticle synergies for on-demand drug deliverycitations
- 2015Biodegradation of carbon nanohorns in macrophage cells.citations
- 2015Degradation-by-design: Surface modification with functional substrates that enhance the enzymatic degradation of carbon nanotubescitations
- 2015Nanocomposite Hydrogels: 3D Polymer-Nanoparticle Synergies for On-Demand Drug Delivery.citations
- 2015Degradation-by-design: Surface modification with functional substrates that enhance the enzymatic degradation of carbon nanotubes.citations
- 2015Degradation-by-design: Surface modification with functional substrates that enhance the enzymatic degradation of carbon nanotubes.citations
- 2015Intracellular degradation of chemically functionalized carbon nanotubes using a long-term primary microglial culture modelcitations
- 2014Biodegradation of Graphene Nanocarbons
- 2010Energy loss of protons in carbon nanotubes: experiments and calculationscitations
Places of action
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article
Enhanced Intraliposomal Metallic Nanoparticle Payload Capacity Using Microfluidic-Assisted Self-Assembly
Abstract
Hybrids composed of liposomes (L) and metallic nanoparticles (NPs) hold great potential for imaging and drug delivery purposes. However, the efficient incorporation of metallic NPs into liposomes using conventional methodologies has so far proved to be challenging. In this study, we report the fabrication of hybrids of liposomes and hydrophobic gold NPs of size 2–4 nm (Au) using a microfluidic-assisted self-assembly process. The incorporation of increasing amounts of AuNPs into liposomes was examined using microfluidics and compared to L–AuNP hybrids prepared by the reverse-phase evaporation method. Our microfluidics strategy produced L–AuNP hybrids with a homogeneous size distribution, a smaller polydispersity index, and a threefold increase in loading efficiency when compared to those hybrids prepared using the reverse-phase method of production. Quantification of the loading efficiency was determined by ultraviolet spectroscopy, inductively coupled plasma mass spectroscopy, and centrifugal field flow fractionation, and qualitative validation was confirmed by transmission electron microscopy. The higher loading of gold NPs into the liposomes achieved using microfluidics produced a slightly thicker and more rigid bilayer as determined with small-angle neutron scattering. These observations were confirmed using fluorescent anisotropy and atomic force microscopy. Structural characterization of the liposomal–NP hybrids with cryo-electron microscopy revealed the coexistence of membrane-embedded and interdigitated NP-rich domains, suggesting AuNP incorporation through hydrophobic interactions. The microfluidic technique that we describe in this study allows for the automated production of monodisperse liposomal–NP hybrids with high loading capacity, highlighting the utility of microfluidics to improve the payload of metallic NPs within liposomes, thereby enhancing their application for imaging and drug delivery.