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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Kinghorn, A. Douglas
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Topics
Publications (3/3 displayed)
- 2023The Cytotoxic Cardiac Glycoside (-)-Cryptanoside A from the Stems of <i>Cryptolepis dubia</i> and Its Molecular Targets.citations
- 2019α-Pyrone and Sterol Constituents of <i>Penicillium aurantiacobrunneum</i>, a Fungal Associate of the Lichen <i>Niebla homalea</i>.citations
- 2017An Intramolecular CAr-H•••O=C Hydrogen Bond and the Configuration of Rotenoids.citations
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article
α-Pyrone and Sterol Constituents of <i>Penicillium aurantiacobrunneum</i>, a Fungal Associate of the Lichen <i>Niebla homalea</i>.
Abstract
Four new metabolites, 4-<i>epi</i>-citreoviridin (<b>1</b>), auransterol (<b>3</b>), and two analogues (<b>2</b> and <b>4</b>) of paxisterol (<b>6</b>), together with two known metabolites (15<i>R</i>*,20<i>S</i>*)-dihydroxyepisterol (<b>5</b>) and (<b>6</b>), were isolated from cultures of the fungal associate, <i>Penicillium aurantiacobrunneum</i>, of the lichen <i>Niebla homalea</i>, endemic to California and Baja California. The structures of all compounds were determined by comprehensive spectroscopic and spectrometric methods, as well as single-crystal X-ray diffraction for the determination of the absolute configuration of <b>3</b>. Compound <b>1</b> showed selective cytotoxicity toward MCF-7 breast and A2780 ovarian cells with IC<sub>50</sub> values of 4.2 and 5.7 μM, respectively.