| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Mukherjee, Partha
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (1/1 displayed)
Places of action
| Organizations | Location | People |
|---|
article
Self-Assembly of Discrete Ru<sup>II</sup><sub>8</sub> Molecular Cages and Their in Vitro Anticancer Activity.
Abstract
Four new octanuclear Ru(II) cages (OC-1-OC-4) were synthesized from dinuclear p-cymene ruthenium(II) acceptors [Ru<sub>2</sub>(μ-η<sup>4</sup>-C<sub>2</sub>O<sub>4</sub>)(CH<sub>3</sub>OH)<sub>2</sub>(η<sup>6</sup>-p-cymene)<sub>2</sub>](O<sub>3</sub>SCF<sub>3</sub>)<sub>2</sub> (A<sub>1</sub>), [Ru<sub>2</sub>(μ-η<sup>4</sup>-C<sub>6</sub>H<sub>2</sub>O<sub>4</sub>)(CH<sub>3</sub>OH)<sub>2</sub>(η<sup>6</sup>-p-cymene)<sub>2</sub>](O<sub>3</sub>SCF<sub>3</sub>)<sub>2</sub> (A<sub>2</sub>), [Ru<sub>2</sub>(dhnq)(H<sub>2</sub>O)<sub>2</sub>(η<sup>6</sup>-p-cymene)<sub>2</sub>](O<sub>3</sub>SCF<sub>3</sub>)<sub>2</sub> (A<sub>3</sub>), and [Ru<sub>2</sub>(dhtq)(H<sub>2</sub>O)<sub>2</sub>(η<sup>6</sup>-p-cymene)<sub>2</sub>](O<sub>3</sub>SCF<sub>3</sub>)<sub>2</sub> (A<sub>4</sub>) separately with a tetradentate pyridyl ligand (L<sub>1</sub>) in methanol using coordination-driven self-assembly [L<sub>1</sub>= N,N,N',N'-tetra(pyridin-4-yl)benzene-1,4-diamine]. The octanuclear cages are fully characterized by various spectroscopic techniques including single-crystal X-ray diffraction analysis of OC-4. The self-assembled cages show strong in vitro anticancer activity against human lung adenocarcinoma A549 and human cervical cancer HeLa cell lines as observed from the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Of all the octanuclear cages, OC-3 exhibits remarkable anticancer activity against both cancer cell lines and is more active than that reported for cisplatin. The excellent anticancer activity of OC-3 and OC-4 highlights the importance of the synergistic effects of the spacer component of the dinuclear p-cymene Ru(II) acceptor clips.