| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Mallet-Ladeira, Sonia
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (8/8 displayed)
- 2024Synthesis, characterization, and inhibition effects of a novel eugenol derivative bearing pyrrole functionalities on the corrosion of mild steel in a HCl acid solutioncitations
- 2023Acetylacetonate Ruthenium Nitrosyls: A Gateway to Nitric Oxide Release in Water Under Near-Infrared Excitation by Two-Photon Absorptioncitations
- 2021Superconducting super-organized nanoparticles of the superconductor (BEDT-TTF)2Cu(NCS)2citations
- 2021Superconducting super-organized nanoparticles of the superconductor (BEDT-TTF)2Cu(NCS)2citations
- 2018Designed single-source precursors for iron germanide nanoparticles: colloidal synthesis and magnetic propertiescitations
- 2017Replacing two chlorido ligands by a bipyridine ligand in ruthenium nitrosyl complexes with NO-release capabilities: A comparative studycitations
- 2016Does the sign of the Cu–Gd magnetic interaction depend on the number of atoms in the bridge?citations
- 2015Iron Complexes with Stabilized Germylenes: Syntheses and Characterizationscitations
Places of action
| Organizations | Location | People |
|---|
article
Acetylacetonate Ruthenium Nitrosyls: A Gateway to Nitric Oxide Release in Water Under Near-Infrared Excitation by Two-Photon Absorption
Abstract
A fundamental challenge for phototriggered therapies is to obtain robust molecular frameworks that withstand biological media. Photoactivatable nitric oxide (NO) releasing molecules (photoNORMs) based on ruthenium nitrosyl (RuNO) complexes lie among the most studied systems due to several appealing features that make them attractive for therapeutic applications. Nevertheless, the propensity of the NO ligand to be attacked by nucleophiles frequently manifests as a significant instability in water for this class of photoNORMs. Our approach to overcome this limitation involved enhancing the Ru-NO π-backbonding to lower the electrophilicity at the NO by replacing the commonly employed 2,2’-bipyridine (bpy) ligand by an anionic, electron-rich, acetylacetonate (acac). A versatile and convenient synthetic route is developed and applied for the preparation of a large library of RuNO photoNORMs with the general formula [RuNO(tpy)(acac)]2+ (tpy=2,2’:6’,2’’-terpyridine). A combined theoretical and experimental analysis of the Ru-NO bonding in these complexes is presented, supported by extensive single-crystal X-Ray diffraction experiments and by topological analyses of the electron charge density by DFT. The enhanced π-backbonding, systematically evidenced by several techniques, resulted in a remarkable stability in water for these complexes, where significant NO release efficiencies were recorded. We finally demonstrate the possibility of obtaining sophisticated water-stable multipolar NO-delivery platforms that can be activated in the near-IR region by two-photon absorption (TPA), as demonstrated for an octupolar complex with a TPA cross section of 1530 GM at λ = 800 nm and for which NO photorelease was demonstrated under TPA irradiation in aqueous media.