| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Caruso, Frank
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (16/16 displayed)
- 2023Protease-Responsive Hydrogel Microparticles for Intradermal Drug Deliverycitations
- 2020Protein Component of Oyster Glycogen Nanoparticlescitations
- 2019The future of layer-by-layer assembly: A tribute to ACS Nano associate editor Helmuth Möhwaldcitations
- 2019Glycogen as a building block for advanced biological materialscitations
- 2018Metal-Organic Frameworks for Cell and Virus Biologycitations
- 2015Surface-Confined Amorphous Films from Metal-Coordinated Simple Phenolic Ligandscitations
- 2015Nanoporous Metal-Phenolic Particles as Ultrasound Imaging Probes for Hydrogen Peroxide.citations
- 2014Tuning particle biodegradation through polymer-peptide blend compositioncitations
- 2012Tailoring the Chain Packing in Ultrathin Polyelectrolyte Films Formed by Sequential Adsorptioncitations
- 2012Synthesis and functionalization of nanoengineered materials using click chemistrycitations
- 2012Engineering cellular degradation of multilayered capsules through controlled cross-linkingcitations
- 2011Nanoengineered films via surface-confined continuous assembly of polymerscitations
- 2009Cholesterol-mediated anchoring of enzyme-loaded liposomes within disulfide-stabilized polymer carrier capsulescitations
- 2009Tuning the formation and degradation of layer-by-layer assembled polymer hydrogel microcapsulescitations
- 2009Stabilization and functionalization of polymer multilayers and capsules via thiol-ene click chemistrycitations
- 2005Optical Properties of Nanoparticle-based Metallodielectric Inverse Opalscitations
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article
Protease-Responsive Hydrogel Microparticles for Intradermal Drug Delivery
Abstract
Protease-responsive multi-arm polyethylene glycol-based microparticles with biscysteine peptide crosslinkers (CGPGG↓LAGGC) were obtained for intradermal drug delivery through inverse suspension photopolymerization. The average size of the spherical hydrated microparticles was ∼40 μm after crosslinking, making them attractive as a skin depot and suitable for intradermal injections, as they are readily dispensable through 27G needles. The effects of exposure to matrix metalloproteinase 9 (MMP-9) on the microparticles were evaluated by scanning electron microscopy and atomic force microscopy, demonstrating partial network destruction and decrease in elastic moduli. Given the recurring course of many skin diseases, the microparticles were exposed to MMP-9 in a flare-up mimicking fashion (multiple-time exposure), showing a significant increase in release of tofacitinib citrate (TC) from the MMP-responsive microparticles, which was not seen for the non-responsive microparticles (polyethylene glycol dithiol crosslinker). It was found that the degree of multi-arm complexity of the polyethylene glycol building blocks can be utilized to tune not only the release profile of TC but also the elastic moduli of the hydrogel microparticles, with Young’s moduli ranging from 14 to 140 kPa going from 4-arm to 8-arm MMP-responsive microparticles. Finally, cytotoxicity studies conducted with skin fibroblasts showed no reduction in metabolic activity after 24 h exposure to the microparticles. Overall, these findings demonstrate that protease-responsive microparticles exhibit the properties of interest for intradermal drug delivery.